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SPG21 and NR1D1
Data Source:
BioGRID
(two hybrid)
SPG21
NR1D1
Description
SPG21 abhydrolase domain containing, maspardin
nuclear receptor subfamily 1 group D member 1
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Intracellular Membrane-bounded Organelle
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Dendrite
Dendritic Spine
Molecular Function
Protein Binding
CD4 Receptor Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Heme Binding
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Glucose Homeostasis
Glycogen Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Circadian Rhythm
Hormone-mediated Signaling Pathway
Proteasomal Protein Catabolic Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Intracellular Receptor Signaling Pathway
Protein Destabilization
Circadian Regulation Of Gene Expression
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cholesterol Homeostasis
Regulation Of Circadian Sleep/wake Cycle
Regulation Of Circadian Rhythm
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Steroid Hormone Mediated Signaling Pathway
Response To Leptin
Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Circadian Temperature Homeostasis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Astrocyte Activation
Positive Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Microglial Cell Activation
Pathways
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Circadian Clock
Circadian Clock
Drugs
SR-9009
SR-9011
Diseases
Hereditary spastic paraplegia (SPG)
GWAS
Asthma (
31619474
)
Mean corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
)
White blood cell count (
21738480
)
Interacting Genes
164 interacting genes:
ACOT13
AGTR1
AGTRAP
AKIRIN2
APOC1
ARL6IP1
ARL8A
ARMC12
ARMC7
ATP5ME
ATPAF2
BORCS6
BSND
C10orf82
C9orf24
CCDC102B
CCDC153
CCDC33
CCHCR1
CD4
CDK2AP1
CDKN2B
CEP76
CEPT1
CFAP410
CIDEB
CLDN22
CMTM4
CMTM5
CMTM6
COG3
COG6
CPSF7
CRX
CRYAA
CRYAA2
CT55
CTIF
CTPS2
CUTC
DCTPP1
DTX2
DTX3L
EFHC2
EIF1B
EIF4H
EYA2
FAM114A1
FAM86C1P
FBXO44
FLACC1
GAD2
GAS8
GEMIN2
GEMIN4
GGA2
GOLGA2
GOLT1B
GRPEL1
GSK3A
HNRNPH1
HPRT1
HSD17B13
IKZF3
INCA1
IQCB1
KCTD9
KRT13
KRT15
KRT19
KRT31
LEPROTL1
LMNA
LMO1
LNX1
LSMEM2
MAB21L3
MID2
MPC2
MTMR9
MTUS2
MYG1
MYOG
N4BP3
NAB2
NDUFAF2
NIF3L1
NME4
NQO2
NR1D1
NRDE2
NUP54
PAX6
PBX4
PCBD2
PCNA
PDE5A
PEF1
PFDN5
PLP2
PNMA5
PPM1J
PRPS1
PRTFDC1
PSMB4
PTPA
RABAC1
RAD51C
REEP6
REL
ROPN1
RPRD1B
RPS19
RTL8B
RTN4
S100B
SATB1
SCAMP1
SEPTIN5
SFT2D1
SH3GL1
SLC35E3
SORBS3
SPRED1
SPRED2
SRGAP2B
SSBP4
SWSAP1
SYNGR1
SYNGR3
SYP
TCF12
TCF4
TEKT4
TFG
TFIP11
TLE5
TMEM208
TMEM239
TOX2
TPD52
TRAF1
TRAF2
TRIB3
TRIM14
TRIM23
TRIM50
TRIM54
TRIM9
TSGA10IP
TSNAXIP1
TTC23L
TXN
TXNL4B
UFSP1
USHBP1
VMAC
VPS25
YPEL3
ZBTB42
ZMYND12
ZNF263
ZNF581
ZNF629
9 interacting genes:
APP
C1D
INPP1
NCOR1
NCOR2
NR1D2
NR2E3
SPG21
TDO2
Entrez ID
51324
9572
HPRD ID
10492
03873
Ensembl ID
ENSG00000090487
ENSG00000126368
Uniprot IDs
A0A024R5Y1
Q9NZD8
F1D8S3
P20393
PDB IDs
1A6Y
1EF6
1GA5
1HLZ
3N00
Enriched GO Terms of Interacting Partners
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