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NR1D1 and NR2E3
Data Source:
HPRD
(two hybrid, in vitro)
NR1D1
NR2E3
Description
nuclear receptor subfamily 1 group D member 1
nuclear receptor subfamily 2 group E member 3
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Dendrite
Dendritic Spine
Nucleus
Nucleoplasm
Transcription Regulator Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Heme Binding
E-box Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Sequence-specific DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Glucose Homeostasis
Glycogen Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Circadian Rhythm
Hormone-mediated Signaling Pathway
Proteasomal Protein Catabolic Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Intracellular Receptor Signaling Pathway
Protein Destabilization
Circadian Regulation Of Gene Expression
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cholesterol Homeostasis
Regulation Of Circadian Sleep/wake Cycle
Regulation Of Circadian Rhythm
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Steroid Hormone Mediated Signaling Pathway
Response To Leptin
Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Circadian Temperature Homeostasis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Astrocyte Activation
Positive Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Microglial Cell Activation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Signal Transduction
Visual Perception
Phototransduction
Negative Regulation Of Cell Population Proliferation
Cell Differentiation
Intracellular Receptor Signaling Pathway
Eye Photoreceptor Cell Development
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Anatomical Structure Development
Retina Development In Camera-type Eye
Pathways
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Circadian Clock
Circadian Clock
Drugs
SR-9009
SR-9011
Diseases
Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
Retinitis pigmentosa (RP)
GWAS
Asthma (
31619474
)
Mean corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
)
White blood cell count (
21738480
)
Hematocrit (
32888494
)
Hemoglobin (
32888494
)
Macular thickness (
30535121
)
Metabolite levels (HVA/MHPG ratio) (
23319000
)
Red blood cell count (
32888494
)
Interacting Genes
9 interacting genes:
APP
C1D
INPP1
NCOR1
NCOR2
NR1D2
NR2E3
SPG21
TDO2
29 interacting genes:
BCL11A
CDK9
CRX
DEDD2
DHX30
ELAVL2
HDAC1
HDAC3
HOXC13
IRF9
MYBBP1A
NCOR1
NR1D1
NR3C1
NRL
POLR3D
PPARG
RARA
RBBP4
RBBP7
RBFOX2
RBL1
RXRA
RXRB
SIN3A
SNAPC1
TBL3
WDR5
ZNF232
Entrez ID
9572
10002
HPRD ID
03873
05132
Ensembl ID
ENSG00000126368
ENSG00000278570
Uniprot IDs
F1D8S3
P20393
F1D8Q9
Q9Y5X4
PDB IDs
1A6Y
1EF6
1GA5
1HLZ
3N00
4LOG
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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