SPG21 and NQO2

Data Source:
BioGRID (two hybrid)

		SPG21	NQO2
Description		SPG21 abhydrolase domain containing, maspardin	N-ribosyldihydronicotinamide:quinone reductase 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Endosome Membrane Trans-Golgi Network Transport Vesicle Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding CD4 Receptor Binding	Dihydronicotinamide Riboside Quinone Reductase Activity NAD(P)H Dehydrogenase (quinone) Activity Protein Binding Zinc Ion Binding Electron Transfer Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Other Nitrogenous Compounds As Donors Chloride Ion Binding Protein Homodimerization Activity FAD Binding Melatonin Binding Resveratrol Binding
	Biological Process	Antigen Receptor-mediated Signaling Pathway	Xenobiotic Metabolic Process Memory Electron Transport Chain Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Phase I - Functionalization of compounds
Drugs			NADH Menadione Melatonin Primaquine Resveratrol Flavin adenine dinucleotide 10-Propargyl-5,8-Dideazafolic Acid Quercetin Tretazicar (3S)-3-hydroxy-1-methyl-2,3-dihydro-1H-indole-5,6-dione N-[2-(2-iodo-5-methoxy-1H-indol-3-yl)ethyl]acetamide 5,8-dimethoxy-1,4-dimethylquinolin-2(1H)-one Casimiroin
Diseases		Hereditary spastic paraplegia (SPG)
GWAS			Blood protein levels ( 30072576 29875488) Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		164 interacting genes: ACOT13 AGTR1 AGTRAP AKIRIN2 APOC1 ARL6IP1 ARL8A ARMC12 ARMC7 ATP5ME ATPAF2 BORCS6 BSND C10orf82 C9orf24 CCDC102B CCDC153 CCDC33 CCHCR1 CD4 CDK2AP1 CDKN2B CEP76 CEPT1 CFAP410 CIDEB CLDN22 CMTM4 CMTM5 CMTM6 COG3 COG6 CPSF7 CRX CRYAA CRYAA2 CT55 CTIF CTPS2 CUTC DCTPP1 DTX2 DTX3L EFHC2 EIF1B EIF4H EYA2 FAM114A1 FAM86C1P FBXO44 FLACC1 GAD2 GAS8 GEMIN2 GEMIN4 GGA2 GOLGA2 GOLT1B GRPEL1 GSK3A HNRNPH1 HPRT1 HSD17B13 IKZF3 INCA1 IQCB1 KCTD9 KRT13 KRT15 KRT19 KRT31 LEPROTL1 LMNA LMO1 LNX1 LSMEM2 MAB21L3 MID2 MPC2 MTMR9 MTUS2 MYG1 MYOG N4BP3 NAB2 NDUFAF2 NIF3L1 NME4 NQO2 NR1D1 NRDE2 NUP54 PAX6 PBX4 PCBD2 PCNA PDE5A PEF1 PFDN5 PLP2 PNMA5 PPM1J PRPS1 PRTFDC1 PSMB4 PTPA RABAC1 RAD51C REEP6 REL ROPN1 RPRD1B RPS19 RTL8B RTN4 S100B SATB1 SCAMP1 SEPTIN5 SFT2D1 SH3GL1 SLC35E3 SORBS3 SPRED1 SPRED2 SRGAP2B SSBP4 SWSAP1 SYNGR1 SYNGR3 SYP TCF12 TCF4 TEKT4 TFG TFIP11 TLE5 TMEM208 TMEM239 TOX2 TPD52 TRAF1 TRAF2 TRIB3 TRIM14 TRIM23 TRIM50 TRIM54 TRIM9 TSGA10IP TSNAXIP1 TTC23L TXN TXNL4B UFSP1 USHBP1 VMAC VPS25 YPEL3 ZBTB42 ZMYND12 ZNF263 ZNF581 ZNF629	7 interacting genes: DDIT4L DGCR6 EFHC1 GORASP2 IL32 LRRC7 SPG21
Entrez ID		51324	4835
HPRD ID		10492	01190
Ensembl ID		ENSG00000090487	ENSG00000124588
Uniprot IDs		A0A024R5Y1 Q9NZD8	B3KPX6 P16083 Q5TD07
PDB IDs			1QR2 1SG0 1XI2 1ZX1 2BZS 2QMY 2QMZ 2QR2 2QWX 2QX4 2QX6 2QX8 2QX9 3FW1 3G5M 3GAM 3NFR 3NHF 3NHJ 3NHK 3NHL 3NHP 3NHR 3NHS 3NHU 3NHW 3NHY 3O2N 3O73 3OVM 3OWH 3OWX 3OX1 3OX2 3OX3 3TE7 3TEM 3TZB 3UXE 3UXH 4FGJ 4FGK 4FGL 4GQI 4GR9 4QOD 4QOE 4QOF 4QOG 4QOH 4QOI 4QOJ 4U7F 4U7G 4U7H 4XDG 4XDH 4ZVK 4ZVL 4ZVM 4ZVN 5BUC 5LBT 5LBU 5LBW 5LBY 5LBZ
Enriched GO Terms of Interacting Partners?
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