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SPG21 and PSMB4
Data Source:
BioGRID
(two hybrid)
SPG21
PSMB4
Description
SPG21 abhydrolase domain containing, maspardin
proteasome 20S subunit beta 4
Image
No pdb structure
GO Annotations
Cellular Component
Golgi Apparatus
Cytosol
Endosome Membrane
Trans-Golgi Network Transport Vesicle
Intracellular Membrane-bounded Organelle
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Beta-subunit Complex
Ciliary Basal Body
Extracellular Exosome
Molecular Function
Protein Binding
CD4 Receptor Binding
Lipopolysaccharide Binding
Endopeptidase Activity
Threonine-type Endopeptidase Activity
Protein Binding
Biological Process
Antigen Receptor-mediated Signaling Pathway
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Diseases
Hereditary spastic paraplegia (SPG)
GWAS
Blood trace element (Cu levels) (
23720494
)
Body mass index (
26426971
)
Interacting Genes
164 interacting genes:
ACOT13
AGTR1
AGTRAP
AKIRIN2
APOC1
ARL6IP1
ARL8A
ARMC12
ARMC7
ATP5ME
ATPAF2
BORCS6
BSND
C10orf82
C9orf24
CCDC102B
CCDC153
CCDC33
CCHCR1
CD4
CDK2AP1
CDKN2B
CEP76
CEPT1
CFAP410
CIDEB
CLDN22
CMTM4
CMTM5
CMTM6
COG3
COG6
CPSF7
CRX
CRYAA
CRYAA2
CT55
CTIF
CTPS2
CUTC
DCTPP1
DTX2
DTX3L
EFHC2
EIF1B
EIF4H
EYA2
FAM114A1
FAM86C1P
FBXO44
FLACC1
GAD2
GAS8
GEMIN2
GEMIN4
GGA2
GOLGA2
GOLT1B
GRPEL1
GSK3A
HNRNPH1
HPRT1
HSD17B13
IKZF3
INCA1
IQCB1
KCTD9
KRT13
KRT15
KRT19
KRT31
LEPROTL1
LMNA
LMO1
LNX1
LSMEM2
MAB21L3
MID2
MPC2
MTMR9
MTUS2
MYG1
MYOG
N4BP3
NAB2
NDUFAF2
NIF3L1
NME4
NQO2
NR1D1
NRDE2
NUP54
PAX6
PBX4
PCBD2
PCNA
PDE5A
PEF1
PFDN5
PLP2
PNMA5
PPM1J
PRPS1
PRTFDC1
PSMB4
PTPA
RABAC1
RAD51C
REEP6
REL
ROPN1
RPRD1B
RPS19
RTL8B
RTN4
S100B
SATB1
SCAMP1
SEPTIN5
SFT2D1
SH3GL1
SLC35E3
SORBS3
SPRED1
SPRED2
SRGAP2B
SSBP4
SWSAP1
SYNGR1
SYNGR3
SYP
TCF12
TCF4
TEKT4
TFG
TFIP11
TLE5
TMEM208
TMEM239
TOX2
TPD52
TRAF1
TRAF2
TRIB3
TRIM14
TRIM23
TRIM50
TRIM54
TRIM9
TSGA10IP
TSNAXIP1
TTC23L
TXN
TXNL4B
UFSP1
USHBP1
VMAC
VPS25
YPEL3
ZBTB42
ZMYND12
ZNF263
ZNF581
ZNF629
35 interacting genes:
APP
BCL6
C1orf109
CCDC57
CNOT2
CUL1
DTX2
FSD2
GABARAPL1
GCA
HEMK1
HGS
KANK2
KRTAP19-5
MYOZ3
OAZ1
P4HA3
PFDN5
PITX2
PKN1
PLK1
PRKCA
PROP1
PRPF19
PSMB1
PSMB5
PSMD2
PSMG3
SMAD1
SOHLH1
SPG21
SYNPO2L
TEKT5
TFAP2D
TLE5
Entrez ID
51324
5692
HPRD ID
10492
03710
Ensembl ID
ENSG00000090487
ENSG00000159377
Uniprot IDs
A0A024R5Y1
Q9NZD8
A0A140VK46
P28070
PDB IDs
4R3O
4R67
5A0Q
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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