NR1D1 and INPP1

Data Source:
BioGRID (two hybrid, two hybrid)

		NR1D1	INPP1
Description		nuclear receptor subfamily 1 group D member 1	inositol polyphosphate-1-phosphatase
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Dendrite Dendritic Spine	Cytosol
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Heme Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Inositol-1,4-bisphosphate 1-phosphatase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Hormone-mediated Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Sleep/wake Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Activation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Microglial Cell Activation	Phosphate-containing Compound Metabolic Process Signal Transduction Inositol Phosphate Metabolic Process Phosphatidylinositol Phosphorylation Inositol Phosphate Dephosphorylation
Pathways		NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Circadian Clock Circadian Clock	Synthesis of IP2, IP, and Ins in the cytosol
Drugs		SR-9009 SR-9011
Diseases
GWAS		Asthma ( 31619474) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) White blood cell count ( 21738480)	Arthritis (juvenile idiopathic) ( 33106285) Daytime sleep phenotypes ( 27126917) Lung cancer (SNP x SNP interaction) ( 24325914) Machado-Joseph disease (age at onset) ( 32205469)
Interacting Genes		9 interacting genes: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3 SPG21 TDO2	11 interacting genes: BBLN BRCA1 DYNLL1 LDOC1 LIG1 MEOX2 NDC80 NECAB2 NR1D1 SYCE3 USHBP1
Entrez ID		9572	3628
HPRD ID		03873	00923
Ensembl ID		ENSG00000126368	ENSG00000151689
Uniprot IDs		F1D8S3 P20393	P49441 Q6IBG4
PDB IDs		1A6Y 1EF6 1GA5 1HLZ 3N00
Enriched GO Terms of Interacting Partners?
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