NR1D1 and C1D

Data Source:
BioGRID (pull down, affinity chromatography technology)

		NR1D1	C1D
Description		nuclear receptor subfamily 1 group D member 1	C1D nuclear receptor corepressor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Dendrite Dendritic Spine	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Heme Binding E-box Binding Sequence-specific Double-stranded DNA Binding	DNA Binding RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Hormone-mediated Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Sleep/wake Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Activation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Microglial Cell Activation	Maturation Of 5.8S RRNA RRNA Processing Apoptotic Process Regulation Of Gene Expression
Pathways		NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Circadian Clock Circadian Clock	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		SR-9009 SR-9011
Diseases
GWAS		Asthma ( 31619474) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) White blood cell count ( 21738480)	Familial lung adenocarcinoma ( 29924316) Male-pattern baldness ( 27182965) Obstetric antiphospholipid syndrome ( 28424481) PR interval ( 32439900) Restless legs syndrome ( 29029846) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415)
Interacting Genes		9 interacting genes: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3 SPG21 TDO2	15 interacting genes: APP GSC2 IL23R NCOR1 NCOR2 NR1D1 PCBD2 PRKDC SASH1 SH3GLB1 SUOX THRA THRB TSNAX ZGPAT
Entrez ID		9572	10438
HPRD ID		03873	07382
Ensembl ID		ENSG00000126368	ENSG00000197223
Uniprot IDs		F1D8S3 P20393	Q13901
PDB IDs		1A6Y 1EF6 1GA5 1HLZ 3N00
Enriched GO Terms of Interacting Partners?
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