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NR1D1 and C1D
Data Source:
BioGRID
(pull down, affinity chromatography technology)
NR1D1
C1D
Description
nuclear receptor subfamily 1 group D member 1
C1D nuclear receptor corepressor
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Dendrite
Dendritic Spine
Nuclear Exosome (RNase Complex)
Exosome (RNase Complex)
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Heme Binding
E-box Binding
Sequence-specific Double-stranded DNA Binding
DNA Binding
RNA Binding
Protein Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Glucose Homeostasis
Glycogen Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Circadian Rhythm
Hormone-mediated Signaling Pathway
Proteasomal Protein Catabolic Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Intracellular Receptor Signaling Pathway
Protein Destabilization
Circadian Regulation Of Gene Expression
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cholesterol Homeostasis
Regulation Of Circadian Sleep/wake Cycle
Regulation Of Circadian Rhythm
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Steroid Hormone Mediated Signaling Pathway
Response To Leptin
Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Circadian Temperature Homeostasis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Astrocyte Activation
Positive Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Microglial Cell Activation
Maturation Of 5.8S RRNA
RRNA Processing
Apoptotic Process
Regulation Of Gene Expression
Pathways
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Circadian Clock
Circadian Clock
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
SR-9009
SR-9011
Diseases
GWAS
Asthma (
31619474
)
Mean corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
)
White blood cell count (
21738480
)
Familial lung adenocarcinoma (
29924316
)
Male-pattern baldness (
27182965
)
Obstetric antiphospholipid syndrome (
28424481
)
PR interval (
32439900
)
Restless legs syndrome (
29029846
)
Systolic blood pressure response to hydrochlorothiazide in hypertension (
27802415
)
Interacting Genes
9 interacting genes:
APP
C1D
INPP1
NCOR1
NCOR2
NR1D2
NR2E3
SPG21
TDO2
15 interacting genes:
APP
GSC2
IL23R
NCOR1
NCOR2
NR1D1
PCBD2
PRKDC
SASH1
SH3GLB1
SUOX
THRA
THRB
TSNAX
ZGPAT
Entrez ID
9572
10438
HPRD ID
03873
07382
Ensembl ID
ENSG00000126368
ENSG00000197223
Uniprot IDs
F1D8S3
P20393
Q13901
PDB IDs
1A6Y
1EF6
1GA5
1HLZ
3N00
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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