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NR1D1 and NR1D2
Data Source:
HPRD
(two hybrid)
NR1D1
NR1D2
Description
nuclear receptor subfamily 1 group D member 1
nuclear receptor subfamily 1 group D member 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
Dendrite
Dendritic Spine
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Corepressor Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Heme Binding
E-box Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Glucose Homeostasis
Glycogen Biosynthetic Process
Transcription Initiation From RNA Polymerase II Promoter
Circadian Rhythm
Hormone-mediated Signaling Pathway
Proteasomal Protein Catabolic Process
Regulation Of Lipid Metabolic Process
Cell Differentiation
Intracellular Receptor Signaling Pathway
Protein Destabilization
Circadian Regulation Of Gene Expression
Negative Regulation Of Toll-like Receptor 4 Signaling Pathway
Cholesterol Homeostasis
Regulation Of Circadian Sleep/wake Cycle
Regulation Of Circadian Rhythm
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Steroid Hormone Mediated Signaling Pathway
Response To Leptin
Regulation Of Fat Cell Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Inflammatory Response
Circadian Temperature Homeostasis
Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Regulation Of Type B Pancreatic Cell Proliferation
Negative Regulation Of Astrocyte Activation
Positive Regulation Of Bile Acid Biosynthetic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Neuroinflammatory Response
Negative Regulation Of Microglial Cell Activation
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Transcription Initiation From RNA Polymerase II Promoter
Hormone-mediated Signaling Pathway
Regulation Of Lipid Metabolic Process
Cell Differentiation
Intracellular Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Circadian Behavior
Regulation Of Inflammatory Response
Negative Regulation Of Inflammatory Response
Lipid Homeostasis
Energy Homeostasis
Regulation Of Skeletal Muscle Cell Differentiation
Pathways
NR1D1 (REV-ERBA) represses gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Nuclear Receptor transcription pathway
Circadian Clock
Circadian Clock
Nuclear Receptor transcription pathway
Drugs
SR-9009
SR-9011
SR-9009
SR-9011
Diseases
GWAS
Asthma (
31619474
)
Mean corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
)
White blood cell count (
21738480
)
Acne (severe) (
24927181
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Asthma (
29273806
)
Cognitive ability (
29186694
)
Extremely high intelligence (
29520040
)
General cognitive ability (
29844566
)
Intelligence (
28530673
)
Intelligence (MTAG) (
29326435
)
Metabolite levels (
23823483
)
Parkinson's disease progression (cognitive) (
33111402
)
Refractive error (
32231278
)
Interacting Genes
9 interacting genes:
APP
C1D
INPP1
NCOR1
NCOR2
NR1D2
NR2E3
SPG21
TDO2
53 interacting genes:
CRY1
CSNK1E
CSNK2A2
CUL1
CYSRT1
DELEC1
EFEMP2
GTF2B
HDAC1
HOXA1
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP3-2
KRTAP3-3
KRTAP4-2
KRTAP5-6
KRTAP6-2
KRTAP9-2
KRTAP9-3
KRTAP9-8
LGALS8
MEOX2
MID2
MYLIP
MYO15B
NBPF19
NCOA5
NCOR1
NOTCH2NLA
NR1D1
PCSK5
PRMT6
PROP1
RBPMS
RGN
RORC
SIN3B
TAF6
TAF9
TBC1D21
TENT5B
TRIM27
TRIM55
TRIM63
TRIP6
UBE2I
ZNF587
Entrez ID
9572
9975
HPRD ID
03873
03809
Ensembl ID
ENSG00000126368
ENSG00000174738
Uniprot IDs
F1D8S3
P20393
B4DXD3
F1D8P2
Q14995
PDB IDs
1A6Y
1EF6
1GA5
1HLZ
3N00
2V0V
2V7C
3CQV
4N73
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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