PCSK5 and INCA1

Data Source:
BioGRID (two hybrid)

		PCSK5	INCA1
Description		proprotein convertase subtilisin/kexin type 5	inhibitor of CDK, cyclin A1 interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane Secretory Granule Integral Component Of Golgi Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Peptide Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Kidney Development Renin Secretion Into Blood Stream Signal Peptide Processing Cell-cell Signaling Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Regulation Of Lipoprotein Lipase Activity Cytokine Precursor Processing	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway
Pathways		NGF processing Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Apolipoprotein B levels ( 32203549) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 28552196 20881960 25282103 23563607 31562340) Hypotension and cognitive impairment ( 31362389) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 29785010 31959993 30054594) LDL cholesterol levels ( 32203549) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Low density lipoprotein cholesterol levels ( 32154731) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Intraocular pressure ( 29235454) Obesity-related traits ( 23251661)
Interacting Genes		69 interacting genes: ADAMTSL4 AMH APPBP2 ATN1 C17orf50 C22orf39 CACNA1A CCDC33 CREB5 CYSRT1 DBF4B DOCK2 FAM86C1P FARS2 FRS3 GLRX3 GUCD1 HOXA1 HOXB9 INCA1 ITGA6 KRTAP1-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP13-3 KRTAP19-2 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 LCE1D LCE1F LCE2C LCE3C LCE3D MDFI MEOX2 NBPF19 NOTCH2NLA NR1D2 NR4A3 NUFIP2 OTX1 PCSK6 PLSCR4 PMCH POU4F2 PTPRM REN SHFL SMCP SPRY1 SSC4D STK16 TEKT4 TLE5 TRAF4 TRIB3 TRIM42 TRIP13 USP54 VGLL3 ZNF547 ZNF655 ZNF837	236 interacting genes: ABI2 ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C19orf54 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13 EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PPP1R32 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SCNM1 SEC14L4 SHFL SLC22A18AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2
Entrez ID		5125	388324
HPRD ID		08985	17150
Ensembl ID		ENSG00000099139	ENSG00000196388
Uniprot IDs		Q92824	Q0VD86
PDB IDs
Enriched GO Terms of Interacting Partners?
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