INCA1 and POU4F2

Data Source:
BioGRID (two hybrid)

		INCA1	POU4F2
Description		inhibitor of CDK, cyclin A1 interacting protein 1	POU class 4 homeobox 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Chromatin Euchromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific P53 Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Regulation Of Transcription By RNA Polymerase II Spermatogenesis Axon Guidance Heart Development Sensory Perception Of Sound Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Neuron Differentiation Intracellular Estrogen Receptor Signaling Pathway Retinal Ganglion Cell Axon Guidance Cellular Response To Insulin Stimulus Positive Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Import Axon Extension Neuromuscular Process Controlling Balance Regulation Of DNA-binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Cytokine Stimulus Cellular Response To Estradiol Stimulus Cellular Response To Oxygen Levels Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Retinal Ganglion Cell Axon Guidance Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Amacrine Cell Differentiation Negative Regulation Of Adipose Tissue Development Dorsal Root Ganglion Development Positive Regulation Of Transcription Regulatory Region DNA Binding
Pathways			Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Intraocular pressure ( 29235454) Obesity-related traits ( 23251661)	Malaria ( 31844061) Metabolite levels ( 23823483)
Interacting Genes		236 interacting genes: ABI2 ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C19orf54 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13 EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PPP1R32 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SCNM1 SEC14L4 SHFL SLC22A18AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2	75 interacting genes: ADAMTSL4 ALPP CCN3 CD46 CERCAM CHIC2 CHRD CHRDL2 COL8A1 CYP21A2 CYSRT1 DLX3 ESR1 FAM86C1P GRN HDHD3 HIGD2B IGFBP6 IGFL1 INCA1 KPRP KRT31 KRT35 KRT38 KRT83 KRTAP10-1 KRTAP10-11 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP19-2 KRTAP19-6 KRTAP19-7 KRTAP21-2 KRTAP3-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE1F LCE5A LCN2 LGALS13 LHX2 LYPD2 MMADHC NFKBID NOTO PCSK5 PLSCR2 RBP3 RBPMS RGS19 SPRY4 TGFB1 TRIM42 VWC2
Entrez ID		388324	5458
HPRD ID		17150	00220
Ensembl ID		ENSG00000196388	ENSG00000151615
Uniprot IDs		Q0VD86	Q12837
PDB IDs
Enriched GO Terms of Interacting Partners?
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