Description |
proprotein convertase subtilisin/kexin type 5 |
MyoD family inhibitor |
Image |
No pdb structure |
No pdb structure |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alzheimer's disease progression score ( 29860282)
- Amyotrophic lateral sclerosis (age of onset) ( 22959728)
- Ankylosing spondylitis ( 30946743)
- Apolipoprotein B levels ( 32203549)
- Body fat distribution (leg fat ratio) ( 30664634)
- Body fat distribution (trunk fat ratio) ( 30664634)
- Diverticular disease ( 30177863)
- Glucocorticoid-induced osteonecrosis ( 26265699)
- Glucose homeostasis traits ( 25524916)
- Height ( 28552196 20881960 25282103 23563607 31562340)
- Hypotension and cognitive impairment ( 31362389)
- Inflammatory bowel disease ( 27569725)
- Intraocular pressure ( 29785010 31959993 30054594)
- LDL cholesterol levels ( 32203549)
- LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Lead levels ( 26025379)
- Low density lipoprotein cholesterol levels ( 32154731)
- Male fertility ( 22633400)
- Metabolite levels (5-HIAA) ( 23319000)
- Pursuit maintenance gain ( 29064472)
- Response to fenofibrate (adiponectin levels) ( 23149075)
- Systemic sclerosis ( 30247649)
- Takayasu arteritis ( 25604533)
- Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
- Vascular brain injury ( 25188341)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412)
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- Grapefruit juice consumption ( 31046077)
- Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
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Interacting Genes |
69 interacting genes:
ADAMTSL4
AMH
APPBP2
ATN1
C17orf50
C22orf39
CACNA1A
CCDC33
CREB5
CYSRT1
DBF4B
DOCK2
FAM86C1P
FARS2
FRS3
GLRX3
GUCD1
HOXA1
HOXB9
INCA1
ITGA6
KRTAP1-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-2
KRTAP3-1
KRTAP3-2
KRTAP4-12
KRTAP5-9
LCE1D
LCE1F
LCE2C
LCE3C
LCE3D
MDFI
MEOX2
NBPF19
NOTCH2NLA
NR1D2
NR4A3
NUFIP2
OTX1
PCSK6
PLSCR4
PMCH
POU4F2
PTPRM
REN
SHFL
SMCP
SPRY1
SSC4D
STK16
TEKT4
TLE5
TRAF4
TRIB3
TRIM42
TRIP13
USP54
VGLL3
ZNF547
ZNF655
ZNF837
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405 interacting genes:
AANAT
AASDHPPT
ABCF3
ABHD11
ABHD17A
ADAMTSL3
ADRA2C
AEBP2
AGXT
AKAP17A
AP5Z1
APLN
AQP1
AQP5
ARHGAP32
ARID5A
ARMC7
ATG12
ATN1
ATP5F1D
ATP6V0C
ATXN7L2
AVPI1
AXIN1
B3GNT9
BAALC
BAG3
BAHD1
BANP
BBS2
BCAM
BCL6
BCL6B
BEX1
BEX2
BEX3
C10orf62
C1orf216
C22orf39
C4orf45
C8orf33
C8orf48
CATSPER1
CBFA2T2
CBLL2
CBX2
CBX8
CC2D1B
CCDC116
CCDC120
CCDC185
CCDC187
CCDC198
CCDC33
CCER1
CCNL2
CDC20B
CDC37
CDC42EP1
CDCA7L
CDKL3
CEP57L1
CFAP206
CHIC2
CHP2
CHRNG
CLPB
CNNM3
CRACR2A
CREB5
CRH
CRX
CRY1
CSNK1G2-AS1
CSNK1G3
CTRC
CXCL16
CYBA
DAAM2
DBF4B
DCAF6
DCAF8
DCANP1
DDX19A
DHRS1
DKK1
DMRT3
DNAJB13
DNMT3A
DNPEP
DOCK2
DOK3
DUSP6
DYNLT4
EBI3
EFEMP2
EIF4A2
EIF4E2
ELOA
ENKD1
ETNK2
EWSR1
FAAP100
FADS6
FAM120AOS
FAM124B
FAM161A
FAM161B
FAM214B
FAM27E3
FAM90A1
FARS2
FASTK
FBXL18
FBXO34
FBXW5
FES
FEZF1
FNDC11
FOXD4
FOXD4L1
FOXD4L3
FOXD4L6
FZD9
GABRD
GATA1
GATA2
GDF15
GLIDR
GLRX3
GNAI2
GNE
GNG5
GPANK1
GPATCH2L
GPRIN2
GREM1
GTF3C5
HAPLN2
HASPIN
HEYL
HHEX
HHLA3
HNRNPLL
HOXA1
HOXB9
HPCAL1
HTR1B
HYPK
IFRD2
ILF3
INTS11
IQUB
ITGB4
JOSD1
KANSL1
KAT5
KCTD7
KIAA0040
KIAA0408
KIF1A
KLHL38
KPNA2
KRAS
KRT77
LAMB3
LASP1
LCE1A
LCE1B
LCE1D
LCE1F
LCE2B
LCE3A
LCE3C
LCE3D
LCE3E
LCE4A
LIMS2
LIN7A
LINC00636
LINC01588
LMO3
LRCH4
LRRN4
MACIR
MAGEC3
MAGED1
MAGEF1
MAPK1
MAPKBP1
MBD3L2
MCM5
MEOX2
METTL17
MFSD3
MGAT5B
MRPL20-AS1
MVP
MXI1
MYF5
MYOD1
MYOG
MYPOP
NAB2
NDUFA7
NECTIN2
NEU4
NIBAN3
NKD1
NOL4L-DT
NPDC1
NPEPL1
NR1H2
NR1H3
NSD1
NTAQ1
NUBP2
NUFIP2
ODAD4
ODAPH
ODF1
ODF3B
OLIG3
OTX1
PARP11
PATZ1
PBXIP1
PCSK5
PDGFA
PDGFB
PDIA5
PDS5A
PELI2
PGLS
PHF1
PHLDA1
PIBF1
PID1
PIDD1
PIH1D2
PIN1
PKD2
PLEKHG4
POLL
POM121L8P
PRKAB2
PRPF18
PRPF31
PRR34
PTK7
PTPMT1
RABL6
RAC1
RASD1
REG3A
REX1BD
RFX2
RHOXF2
RIN1
RIPPLY1
RNF111
RNF6
RTP5
SAPCD2
SCAMP4
SCNM1
SELENOM
SEMA3B
SERF2
SFI1
SHFL
SHMT1
SIX1
SLC13A5
SLC15A3
SLC25A10
SLC35A2
SLC9A1
SMYD1
SNX18
SOCS7
SPATA24
SPATA3
SPATA8
SPG7
SPON1
SPRED2
SPRY1
SPRY2
SUOX
TACO1
TAP1
TASOR2
TBC1D3B
TBC1D3G
TCEANC
TCF3
TEAD4
TEDC2
TGIF1
TH
THAP7
THEG
TIE1
TINAGL1
TLE5
TMEM241
TMIE
TNNI1
TNP2
TOR1A
TRAF3IP2
TRIB3
TRPC1
TRPV6
TSC2
TSFM
TSGA10IP
TSPAN4
TSPYL1
TSPYL6
TTC23
TTLL10
TUSC2
TXN2
TYMSOS
TYRO3
USP20
USP6
VASN
VGLL3
VHL
VPS72
VSTM4
WDFY3
WNT11
YPEL3
YY1
ZBBX
ZBTB24
ZBTB25
ZBTB42
ZBTB9
ZC3HAV1
ZDHHC1
ZFYVE26
ZIM2
ZNF101
ZNF12
ZNF124
ZNF136
ZNF138
ZNF155
ZNF205
ZNF221
ZNF223
ZNF23
ZNF230
ZNF264
ZNF266
ZNF330
ZNF408
ZNF414
ZNF417
ZNF426
ZNF433
ZNF438
ZNF439
ZNF440
ZNF441
ZNF446
ZNF461
ZNF479
ZNF490
ZNF491
ZNF497
ZNF512B
ZNF524
ZNF559
ZNF564
ZNF572
ZNF575
ZNF578
ZNF580
ZNF581
ZNF587
ZNF607
ZNF613
ZNF646
ZNF648
ZNF662
ZNF669
ZNF670
ZNF679
ZNF688
ZNF696
ZNF707
ZNF764
ZNF784
ZNF785
ZNF786
ZNF79
ZNF837
ZNF844
ZNHIT1
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Entrez ID |
5125 |
4188 |
HPRD ID |
08985 |
07280 |
Ensembl ID |
ENSG00000099139
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ENSG00000112559
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Uniprot IDs |
Q92824
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A0A024RCY2
B1AKB6
Q99750
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PDB IDs |
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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