Description |
proprotein convertase subtilisin/kexin type 5 |
phenylalanyl-tRNA synthetase 2, mitochondrial |
Image |
No pdb structure |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alzheimer's disease progression score ( 29860282)
- Amyotrophic lateral sclerosis (age of onset) ( 22959728)
- Ankylosing spondylitis ( 30946743)
- Apolipoprotein B levels ( 32203549)
- Body fat distribution (leg fat ratio) ( 30664634)
- Body fat distribution (trunk fat ratio) ( 30664634)
- Diverticular disease ( 30177863)
- Glucocorticoid-induced osteonecrosis ( 26265699)
- Glucose homeostasis traits ( 25524916)
- Height ( 28552196 20881960 25282103 23563607 31562340)
- Hypotension and cognitive impairment ( 31362389)
- Inflammatory bowel disease ( 27569725)
- Intraocular pressure ( 29785010 31959993 30054594)
- LDL cholesterol levels ( 32203549)
- LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Lead levels ( 26025379)
- Low density lipoprotein cholesterol levels ( 32154731)
- Male fertility ( 22633400)
- Metabolite levels (5-HIAA) ( 23319000)
- Pursuit maintenance gain ( 29064472)
- Response to fenofibrate (adiponectin levels) ( 23149075)
- Systemic sclerosis ( 30247649)
- Takayasu arteritis ( 25604533)
- Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
- Vascular brain injury ( 25188341)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412)
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- Change in glucose in response to thiazide diuretic treatment in hypertension ( 29523524)
- Copper levels ( 26025379)
- Height ( 28552196)
- JT interval (sulfonylurea treatment interaction) ( 27958378)
- Metabolite levels ( 23823483)
- Obesity (early onset extreme) ( 23563609)
- Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306)
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Interacting Genes |
69 interacting genes:
ADAMTSL4
AMH
APPBP2
ATN1
C17orf50
C22orf39
CACNA1A
CCDC33
CREB5
CYSRT1
DBF4B
DOCK2
FAM86C1P
FARS2
FRS3
GLRX3
GUCD1
HOXA1
HOXB9
INCA1
ITGA6
KRTAP1-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-2
KRTAP3-1
KRTAP3-2
KRTAP4-12
KRTAP5-9
LCE1D
LCE1F
LCE2C
LCE3C
LCE3D
MDFI
MEOX2
NBPF19
NOTCH2NLA
NR1D2
NR4A3
NUFIP2
OTX1
PCSK6
PLSCR4
PMCH
POU4F2
PTPRM
REN
SHFL
SMCP
SPRY1
SSC4D
STK16
TEKT4
TLE5
TRAF4
TRIB3
TRIM42
TRIP13
USP54
VGLL3
ZNF547
ZNF655
ZNF837
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69 interacting genes:
ADAMTSL4
AGTRAP
AJUBA
AP1B1
APPL1
BACH2
BAG4
BANP
BEX5
CALCOCO2
CBY2
CCDC152
CDCA4
CMTM5
CYSRT1
DGAT2L6
DPH2
DVL3
FHL5
FKBP7
FSD2
GRB10
HIGD1C
HMBOX1
HOMEZ
IKZF3
ISY1-RAB43
KCNF1
KCTD17
KRT13
KRT31
KRT34
KRT40
KRTAP1-1
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP3-3
MAN1C1
MDFI
MESD
MID2
MKRN3
MORN3
NFKBID
NOTCH2NLA
PCSK5
PPP1R16B
RCBTB2
RIMBP3C
SPRY1
STX11
SYP
TADA2A
TEPSIN
TFCP2
TPM2
TRAF2
TRIM27
TRIM54
TRIP6
YIF1A
ZNF438
ZNF500
ZNF526
ZNF655
ZRANB1
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Entrez ID |
5125 |
10667 |
HPRD ID |
08985 |
09946 |
Ensembl ID |
ENSG00000099139
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ENSG00000145982
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Uniprot IDs |
Q92824
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O95363
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PDB IDs |
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3CMQ
3HFV
3TEG
3TUP
5MGH
5MGU
5MGV
5MGW
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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