INCA1 and TRAPPC6A

Data Source:
BioGRID (two hybrid)

		INCA1	TRAPPC6A
Description		inhibitor of CDK, cyclin A1 interacting protein 1	trafficking protein particle complex subunit 6A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body	Golgi Membrane Endoplasmic Reticulum Cis-Golgi Network Trans-Golgi Network Cytosol TRAPP Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Cyclin Binding Identical Protein Binding Protein-containing Complex Binding	Protein Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Apoptotic Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Regulation Of GTPase Activity COPII Vesicle Coating Melanosome Assembly
Pathways			COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs			S-palmitoyl-L-cysteine
Diseases
GWAS		Intraocular pressure ( 29235454) Obesity-related traits ( 23251661)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Cerebrospinal fluid AB1-42 levels ( 28247064)
Interacting Genes		236 interacting genes: ABI2 ACY3 AKAP8L ANKRD28 ARMC7 ASPSCR1 ATG5 ATP6V0D2 ATPAF2 BAG3 BANF2 BOLA3 BPIFA1 C10orf55 C19orf54 C1orf35 C1orf50 C1orf56 C22orf39 CABP5 CCBE1 CCDC57 CCDC78 CCNA1 CDA CDC23 CDK18 CDK2 CDK4 CDKN1A CDKN2B CDKN2D CEP72 CHCHD2 CHCHD5 CHRD CINP CKS1B CLIC3 CLK3 COL8A1 CPSF1 CSDC2 CSTF2 CTNNBIP1 CTTNBP2 CYSRT1 DAZAP2 DEF6 DMRT3 DMRTB1 DOK4 DPH7 DUSP13 EFEMP2 EMD EPHB6 EXOSC8 FAAP20 FAIM FEM1A FGF16 FHL2 FMR1 FRS3 GEM GEMIN2 GRB2 GRXCR1 GSTO2 GTF2H5 GTPBP3 GYS1 HAUS1 HCK HDAC4 HEMK1 HENMT1 HNRNPF HOMER3 HOXA1 HR HSD17B14 HYI IL36RN ILF2 KCTD7 KCTD9 KIAA1217 KIR2DL4 KLHL26 KLHL42 KRT33B KRT5 KRT75 KRTAP15-1 KRTAP19-1 KRTAP19-5 KRTAP19-6 KRTAP5-6 KRTAP6-2 KRTAP6-3 KRTAP9-3 LENG8 LGALS3 LHX3 LMNTD2 LMO2 LMO3 LSM3 LYPLA2 MAD2L2 MAGED4B MAGOHB MALSU1 MARF1 MARK1 MATN3 MBLAC1 METAP1 MPP1 MSRB1 MTMR9 NATD1 NCK2 NDUFAF3 NEDD9 NEIL2 NEK6 NFKBID NHSL2 NME7 NMRK1 NPAS2 NTAQ1 NUBP2 NUDT16L1 NUDT22 OR6B1 OSGIN1 PADI3 PATE1 PCSK5 PCYT2 PDP1 PEF1 PFDN5 PHF1 PLA2G10 PLSCR3 POLR1C POLR3C POP5 POU4F2 PPP1R32 PRPH PSMB2 PSMB8 PTGER3 R3HDM2 RAB5C RALB RAMAC RBPMS RECK RFC3 RIPPLY3 RNF26 SAP18 SCNM1 SEC14L4 SHFL SLC22A18AS SMG9 SMUG1 SNRPB SPAG8 SPG21 SPOUT1 SPRY1 STAMBPL1 STK16 STT3B SUOX TBC1D7 TCL1A TEAD4 TEKT4 TEX12 TFAP2A TFAP2D TFAP4 TFG THAP6 THRSP TIAL1 TPRX1 TRAPPC2 TRAPPC2B TRAPPC6A TRIB3 TRIM26 TRIM55 TRIM63 TRIM68 TRIP13 TRIP6 TSEN15 TSG101 TSSK3 TSTD2 TXNDC17 UBASH3B UBE2D4 UBE2Z UBTD2 UBXN2B UFM1 UFSP1 VEZF1 VGLL3 VPS26C VPS28 WWOX YIPF3 YOD1 ZDHHC24 ZFAND3 ZMYND12 ZMYND19 ZNF205-AS1 ZNF32 ZNF446 ZNF747 ZNF765 ZNRD2	47 interacting genes: BAG4 CAVIN2 CD2BP2 CRYAB CTDSP1 EFS EYA2 FOXN1 GGA3 GINS3 GOLGA6A GORASP2 HOXA1 HSPB8 IKZF3 INCA1 KANK4 KRTAP13-2 LHX4 MYOZ3 PAX6 PFDN5 PRR22 RAB3IP RAD54B REL RUSC1 SCOC SERTAD3 SF3B5 SMUG1 TAX1BP1 TEPSIN TRAPPC10 TRAPPC12 TRAPPC2 TRAPPC2L TRAPPC3 TRAPPC3L TRAPPC6B TRIM35 TTC23 UBAP2 YPEL3 ZFP90 ZMIZ2 ZNRD2
Entrez ID		388324	79090
HPRD ID		17150	14503
Ensembl ID		ENSG00000196388	ENSG00000007255
Uniprot IDs		Q0VD86	B7TZ90 O75865
PDB IDs			2C0J 2J3T
Enriched GO Terms of Interacting Partners?
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