Description |
proprotein convertase subtilisin/kexin type 5 |
keratin associated protein 1-1 |
Image |
No pdb structure |
No pdb structure |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alzheimer's disease progression score ( 29860282)
- Amyotrophic lateral sclerosis (age of onset) ( 22959728)
- Ankylosing spondylitis ( 30946743)
- Apolipoprotein B levels ( 32203549)
- Body fat distribution (leg fat ratio) ( 30664634)
- Body fat distribution (trunk fat ratio) ( 30664634)
- Diverticular disease ( 30177863)
- Glucocorticoid-induced osteonecrosis ( 26265699)
- Glucose homeostasis traits ( 25524916)
- Height ( 28552196 20881960 25282103 23563607 31562340)
- Hypotension and cognitive impairment ( 31362389)
- Inflammatory bowel disease ( 27569725)
- Intraocular pressure ( 29785010 31959993 30054594)
- LDL cholesterol levels ( 32203549)
- LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Lead levels ( 26025379)
- Low density lipoprotein cholesterol levels ( 32154731)
- Male fertility ( 22633400)
- Metabolite levels (5-HIAA) ( 23319000)
- Pursuit maintenance gain ( 29064472)
- Response to fenofibrate (adiponectin levels) ( 23149075)
- Systemic sclerosis ( 30247649)
- Takayasu arteritis ( 25604533)
- Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
- Vascular brain injury ( 25188341)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412)
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Interacting Genes |
69 interacting genes:
ADAMTSL4
AMH
APPBP2
ATN1
C17orf50
C22orf39
CACNA1A
CCDC33
CREB5
CYSRT1
DBF4B
DOCK2
FAM86C1P
FARS2
FRS3
GLRX3
GUCD1
HOXA1
HOXB9
INCA1
ITGA6
KRTAP1-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-2
KRTAP3-1
KRTAP3-2
KRTAP4-12
KRTAP5-9
LCE1D
LCE1F
LCE2C
LCE3C
LCE3D
MDFI
MEOX2
NBPF19
NOTCH2NLA
NR1D2
NR4A3
NUFIP2
OTX1
PCSK6
PLSCR4
PMCH
POU4F2
PTPRM
REN
SHFL
SMCP
SPRY1
SSC4D
STK16
TEKT4
TLE5
TRAF4
TRIB3
TRIM42
TRIP13
USP54
VGLL3
ZNF547
ZNF655
ZNF837
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189 interacting genes:
ADAM12
ADAMTSL3
ADAMTSL4
AGXT
AKR7A3
ALDH3B1
ALPP
AQP1
ASPSCR1
ATG9A
BCAM
C10orf62
C11orf87
C19orf38
CAMK2B
CATIP
CATSPER1
CD300LG
CERK
CHIC2
CHRD
CHRNG
CLDN2
CNNM3
CRY2
CSF1
CST2
CTRC
CTSZ
CYHR1
CYSLTR2
CYSRT1
DHRS1
DMRT3
DOCK2
EFNA3
EMC7
FAM221A
FAM71C
FAM76B
FAM90A1
FARS2
FEZF1
FKBP1B
FOXD4L3
FRS3
FZD10
GLP1R
GNE
GRN
GSTP1
GUCD1
HCK
HEY2
HOXA1
HOXB5
HOXB9
HOXC8
HPCAL1
HSBP1
HYAL2
IFITM2
IGSF8
IL16
INS
ITGB4
ITGB5
JOSD1
KLHL38
KLK8
KRT20
KRTAP10-1
KRTAP10-11
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-3
KRTAP13-2
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP4-12
KRTAP4-5
KRTAP5-11
KRTAP5-4
KRTAP5-6
KRTAP9-2
KRTAP9-3
KRTAP9-8
LCE1A
LCE1E
LCE1F
LCE2B
LCE2C
LCE2D
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LNX1
LRFN4
LRRN4
MAGOHB
MAPKBP1
MELTF
MGAT5B
MRGBP
MRPL23
MT1B
MXD3
MXI1
MYOM1
NECTIN2
NECTIN3
NMU
NPDC1
NR1D2
NTM
NUBP2
OLIG3
OR14I1
OTX1
P2RX4
P2RY6
PCSK5
PDE9A
PGAP6
PHLDA1
PRKAB2
PRKAG1
PRPF31
PSMA1
PVR
QPRT
R3HDM2
REM2
RNF111
RPS19BP1
RPS28
RPUSD3
RTN4RL1
SCARF1
SCNM1
SDC3
SEMA3B
SHFL
SLC23A1
SLC43A2
SLC6A20
SLC7A11
SLIT1
SMARCE1
SMCP
SMOC1
SNAI1
SNX18
SPACA9
SPRY1
STK16
TCEANC
TFAP2D
TGFB1
TNP2
TSFM
VASN
VGLL3
VSTM4
WNT11
ZBTB48
ZBTB9
ZDHHC1
ZNF124
ZNF330
ZNF408
ZNF439
ZNF440
ZNF446
ZNF491
ZNF497
ZNF524
ZNF581
ZNF587
ZNF648
ZNF669
ZNF696
ZNF786
ZNF837
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Entrez ID |
5125 |
81851 |
HPRD ID |
08985 |
12304 |
Ensembl ID |
ENSG00000099139
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ENSG00000188581
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Uniprot IDs |
Q92824
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Q07627
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PDB IDs |
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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