Description |
proprotein convertase subtilisin/kexin type 5 |
TNF receptor associated factor 4 |
Image |
No pdb structure |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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Diseases |
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GWAS |
- Alzheimer's disease progression score ( 29860282)
- Amyotrophic lateral sclerosis (age of onset) ( 22959728)
- Ankylosing spondylitis ( 30946743)
- Apolipoprotein B levels ( 32203549)
- Body fat distribution (leg fat ratio) ( 30664634)
- Body fat distribution (trunk fat ratio) ( 30664634)
- Diverticular disease ( 30177863)
- Glucocorticoid-induced osteonecrosis ( 26265699)
- Glucose homeostasis traits ( 25524916)
- Height ( 28552196 20881960 25282103 23563607 31562340)
- Hypotension and cognitive impairment ( 31362389)
- Inflammatory bowel disease ( 27569725)
- Intraocular pressure ( 29785010 31959993 30054594)
- LDL cholesterol levels ( 32203549)
- LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716)
- LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)
- Lead levels ( 26025379)
- Low density lipoprotein cholesterol levels ( 32154731)
- Male fertility ( 22633400)
- Metabolite levels (5-HIAA) ( 23319000)
- Pursuit maintenance gain ( 29064472)
- Response to fenofibrate (adiponectin levels) ( 23149075)
- Systemic sclerosis ( 30247649)
- Takayasu arteritis ( 25604533)
- Total ventricular volume (Alzheimer's disease interaction) ( 21116278)
- Vascular brain injury ( 25188341)
- Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625)
- Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625)
- Waist circumference adjusted for BMI in non-smokers ( 28443625)
- Waist circumference adjusted for body mass index ( 25673412)
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Interacting Genes |
69 interacting genes:
ADAMTSL4
AMH
APPBP2
ATN1
C17orf50
C22orf39
CACNA1A
CCDC33
CREB5
CYSRT1
DBF4B
DOCK2
FAM86C1P
FARS2
FRS3
GLRX3
GUCD1
HOXA1
HOXB9
INCA1
ITGA6
KRTAP1-1
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP13-3
KRTAP19-2
KRTAP3-1
KRTAP3-2
KRTAP4-12
KRTAP5-9
LCE1D
LCE1F
LCE2C
LCE3C
LCE3D
MDFI
MEOX2
NBPF19
NOTCH2NLA
NR1D2
NR4A3
NUFIP2
OTX1
PCSK6
PLSCR4
PMCH
POU4F2
PTPRM
REN
SHFL
SMCP
SPRY1
SSC4D
STK16
TEKT4
TLE5
TRAF4
TRIB3
TRIM42
TRIP13
USP54
VGLL3
ZNF547
ZNF655
ZNF837
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131 interacting genes:
ABI3
ALKBH4
BACH2
BAHD1
BANP
BCKDK
BCL6B
BEGAIN
BEX3
BYSL
C19orf54
CALCOCO2
CBL
CBLC
CCHCR1
CENPE
CEP85
CHUK
DISC1
DNM2
DPEP2NB
DTX3
EXOC7
EYA2
EZHIP
FAM214B
FAM90A1
FAT1
FBXL18
FRS3
FTH1
GOLGA2
GOLGA6A
GOLGA6L9
GORASP1
GORASP2
GPRASP1
HEY2
HGS
HMG20A
HOMEZ
HOXA1
HOXB5
IRAK1
ISYNA1
KANK2
KANSL1
KDM1A
KRT31
KRT36
KRT40
LENG8
LNX1
LTBR
MAGEC2
MAGED1
MAP3K4
MRPL28
NCF1
NGFR
NOS1AP
NPAS2
NTRK1
NUDT16L1
PCSK5
PDE4DIP
PHLDA1
PICK1
PKD1P1
PLAGL2
PLEKHA7
PLSCR1
POLR2J
POLR2J3
PSMC3
QARS1
RAD54L2
RBPMS
REXO1L6P
RNF114
RNF144B
RNF4
RPS6KB1
SF3B4
SIGLEC7
SLC9A3R2
SMURF1
SMURF2
SNRPB
SORBS2
SPDL1
SUMO1
TARBP2
TAX1BP1
TBC1D7
TBC1D8
TFAP4
TGFB1I1
TICAM1
TNFRSF4
TP53BP2
TRAF6
TRIM27
TRIM37
TSGA10IP
TYK2
UBE2D1
UBE2I
UBL4A
UBL4B
UBQLN2
USP7
VPS52
WBP11
WWP1
WWP2
ZBTB16
ZBTB26
ZC3H12C
ZMYM5
ZNF177
ZNF275
ZNF3
ZNF512B
ZNF559-ZNF177
ZNF581
ZNF620
ZNF688
ZNF784
ZNF835
ZRANB1
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Entrez ID |
5125 |
9618 |
HPRD ID |
08985 |
03915 |
Ensembl ID |
ENSG00000099139
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ENSG00000076604
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Uniprot IDs |
Q92824
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A0A024QZ19
A0A024QZ59
Q9BUZ4
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PDB IDs |
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2EOD
2YUC
3ZJB
4K8U
4M4E
5YC1
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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