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FIS1 and A2M
Data Source:
BioGRID
(two hybrid)
FIS1
A2M
Description
fission, mitochondrial 1
alpha-2-macroglobulin
Image
GO Annotations
Cellular Component
Mitochondrion
Peroxisome
Integral Component Of Peroxisomal Membrane
Endoplasmic Reticulum
Membrane
Integral Component Of Mitochondrial Outer Membrane
Protein-containing Complex
Extracellular Region
Extracellular Space
Cytosol
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Protein Binding
Identical Protein Binding
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Biological Process
Mitochondrial Fission
Autophagy Of Mitochondrion
Release Of Cytochrome C From Mitochondria
Protein Targeting To Mitochondrion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Peroxisome Fission
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Calcium-mediated Signaling Using Intracellular Calcium Source
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Mitochondrion Morphogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ATP Metabolic Process
Negative Regulation Of Fatty Acid Transport
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Complement Activation, Lectin Pathway
Platelet Degranulation
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Stem Cell Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Class I peroxisomal membrane protein import
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly
Drugs
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Rheumatoid arthritis (
30891314
)
Refractive error (
32231278
)
Interacting Genes
30 interacting genes:
A2M
ABHD6
APH1A
BCAP31
CREB3
DNM1L
EBP
ERGIC3
FAM209A
FAM210B
FFAR2
JAGN1
KASH5
KCNJ6
MARCHF5
MMGT1
NOS3
PIGP
RNASEK
SCN3B
SLC10A6
SLC14A1
SLC22A1
SLC22A2
SPCS1
TBC1D15
TMEM14B
TMPPE
UBC
VKORC1
96 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
Entrez ID
51024
2
HPRD ID
12352
00072
Ensembl ID
ENSG00000214253
ENSG00000175899
Uniprot IDs
Q9Y3D6
P01023
PDB IDs
1NZN
1PC2
1BV8
2P9R
4ACQ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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