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FIS1 and SCN3B
Data Source:
BioGRID
(two hybrid)
FIS1
SCN3B
Description
fission, mitochondrial 1
sodium voltage-gated channel beta subunit 3
Image
GO Annotations
Cellular Component
Mitochondrion
Peroxisome
Integral Component Of Peroxisomal Membrane
Endoplasmic Reticulum
Membrane
Integral Component Of Mitochondrial Outer Membrane
Protein-containing Complex
Voltage-gated Sodium Channel Complex
Plasma Membrane
Integral Component Of Membrane
Z Disc
Molecular Function
Protein Binding
Identical Protein Binding
Voltage-gated Ion Channel Activity
Protein Binding
Sodium Channel Regulator Activity
Sodium Channel Inhibitor Activity
Ion Channel Binding
Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential
Biological Process
Mitochondrial Fission
Autophagy Of Mitochondrion
Release Of Cytochrome C From Mitochondria
Protein Targeting To Mitochondrion
Positive Regulation Of Cytosolic Calcium Ion Concentration
Mitochondrial Fusion
Regulation Of Mitochondrion Organization
Peroxisome Fission
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Calcium-mediated Signaling Using Intracellular Calcium Source
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Mitochondrial Fragmentation Involved In Apoptotic Process
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Mitochondrion Morphogenesis
Positive Regulation Of Mitochondrial Fission
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ATP Metabolic Process
Negative Regulation Of Fatty Acid Transport
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Sodium Ion Transport
Nervous System Development
Positive Regulation Of Heart Rate
Positive Regulation Of Sodium Ion Transport
Sensory Perception Of Pain
Sodium Ion Transmembrane Transport
Membrane Depolarization
Cardiac Muscle Contraction
Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization
Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization
Protein Localization To Plasma Membrane
Cardiac Muscle Cell Action Potential Involved In Contraction
Ventricular Cardiac Muscle Cell Action Potential
Membrane Depolarization During Action Potential
Membrane Depolarization During Cardiac Muscle Cell Action Potential
Atrial Cardiac Muscle Cell Action Potential
SA Node Cell Action Potential
Regulation Of Heart Rate By Cardiac Conduction
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
Class I peroxisomal membrane protein import
Interaction between L1 and Ankyrins
Phase 0 - rapid depolarisation
Drugs
Ranolazine
Valproic acid
Oxcarbazepine
Cocaine
Zonisamide
Brivaracetam
Dichlorobenzyl alcohol
Fish oil
Diseases
Brugada syndrome (BRS)
GWAS
Rheumatoid arthritis (
30891314
)
Chronic lymphocytic leukemia (
28165464
24292274
23770605
)
Response to citalopram or escitalopram in depression (
27622933
)
Interacting Genes
30 interacting genes:
A2M
ABHD6
APH1A
BCAP31
CREB3
DNM1L
EBP
ERGIC3
FAM209A
FAM210B
FFAR2
JAGN1
KASH5
KCNJ6
MARCHF5
MMGT1
NOS3
PIGP
RNASEK
SCN3B
SLC10A6
SLC14A1
SLC22A1
SLC22A2
SPCS1
TBC1D15
TMEM14B
TMPPE
UBC
VKORC1
105 interacting genes:
ADIPOQ
AGPAT4
AGPAT5
ANKRD46
AQP10
ARV1
ATP13A1
ATP6V0C
BNIP1
BNIP3
BRICD5
CLCA4
CTXN3
CYP4F2
DEFB103A
DEFB103B
DERL1
DGAT2L6
ERG28
FAM241B
FAM3C
FIS1
FKBP8
FXYD3
GIMAP1
GIMAP5
GPR151
GPR61
IER3IP1
INSIG2
ISM2
ITGAM
LEMD1
LEPROTL1
LPAR3
MAL2
MARCHF2
MFSD5
MGST3
MS4A13
NFASC
NINJ2
ORMDL1
ORMDL2
PLBD2
PLP2
PLPPR2
PMP22
RHD
RNF8
RUSF1
SACM1L
SCD
SEC22A
SERP2
SFT2D1
SFXN1
SFXN3
SLC2A5
SLC30A3
SLC30A8
SLC35A4
SLC35E4
SLC38A1
SLC38A7
SLC7A1
SMCO4
SMIM1
STRIT1
STX3
STX6
STX8
THSD7A
TIMM23
TM6SF2
TMBIM6
TMEM120A
TMEM120B
TMEM128
TMEM140
TMEM14A
TMEM14B
TMEM208
TMEM239
TMEM243
TMEM42
TMEM50B
TMEM60
TMEM65
TMEM86A
TMPPE
TPRG1
TRARG1
TSPAN2
TVP23B
UBIAD1
USE1
VAMP1
VAMP2
VAMP3
VAPA
VAPB
YIF1A
YIPF4
ZFPL1
Entrez ID
51024
55800
HPRD ID
12352
10497
Ensembl ID
ENSG00000214253
ENSG00000166257
Uniprot IDs
Q9Y3D6
A0A024R3H7
Q9NY72
PDB IDs
1NZN
1PC2
4L1D
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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