FIS1 and ABHD6

Data Source:
BioGRID (two hybrid)

		FIS1	ABHD6
Description		fission, mitochondrial 1	abhydrolase domain containing 6, acylglycerol lipase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Peroxisome Integral Component Of Peroxisomal Membrane Endoplasmic Reticulum Membrane Integral Component Of Mitochondrial Outer Membrane Protein-containing Complex	Mitochondrion Lysosomal Membrane Plasma Membrane Integral Component Of Membrane Late Endosome Membrane Mitochondrial Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Phospholipase Activity Protein Binding Acylglycerol Lipase Activity
	Biological Process	Mitochondrial Fission Autophagy Of Mitochondrion Release Of Cytochrome C From Mitochondria Protein Targeting To Mitochondrion Positive Regulation Of Cytosolic Calcium Ion Concentration Mitochondrial Fusion Regulation Of Mitochondrion Organization Peroxisome Fission Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Fragmentation Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Mitochondrion Morphogenesis Positive Regulation Of Mitochondrial Fission Positive Regulation Of Protein Targeting To Membrane Negative Regulation Of ATP Metabolic Process Negative Regulation Of Fatty Acid Transport Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Phospholipid Catabolic Process Negative Regulation Of Cell Migration Acylglycerol Catabolic Process Positive Regulation Of Lipid Biosynthetic Process Monoacylglycerol Catabolic Process Long-term Synaptic Depression Negative Regulation Of Cold-induced Thermogenesis Regulation Of Endocannabinoid Signaling Pathway Lysobisphosphatidic Acid Metabolic Process
Pathways		Class I peroxisomal membrane protein import	Arachidonate production from DAG
Drugs
Diseases
GWAS		Rheumatoid arthritis ( 30891314)	Hemoglobin levels ( 32327693) Platelet count ( 27863252) Refractive error ( 32231278) Rheumatoid arthritis ( 30423114 24390342) Systemic lupus erythematosus ( 27399966 26502338)
Interacting Genes		30 interacting genes: A2M ABHD6 APH1A BCAP31 CREB3 DNM1L EBP ERGIC3 FAM209A FAM210B FFAR2 JAGN1 KASH5 KCNJ6 MARCHF5 MMGT1 NOS3 PIGP RNASEK SCN3B SLC10A6 SLC14A1 SLC22A1 SLC22A2 SPCS1 TBC1D15 TMEM14B TMPPE UBC VKORC1	6 interacting genes: CKMT2 FIS1 PCGF2 RTP2 SCAMP4 TVP23B
Entrez ID		51024	57406
HPRD ID		12352	12407
Ensembl ID		ENSG00000214253	ENSG00000163686
Uniprot IDs		Q9Y3D6	A0A024R323 Q9BV23
PDB IDs		1NZN 1PC2
Enriched GO Terms of Interacting Partners?
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