NFKBIB and POLR1A

Data Source:
HPRD (in vitro)

		NFKBIB	POLR1A
Description		NFKB inhibitor beta	RNA polymerase I subunit A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleoplasm Chromosome RNA Polymerase I Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Polymerase I Activity DNA Binding Chromatin Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleolus
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS			Facial emotion recognition (sad faces) ( 28608620)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN REL RRN3 TCF4
Entrez ID		4793	25885
HPRD ID		07260	10161
Ensembl ID		ENSG00000104825	ENSG00000068654
Uniprot IDs		G5E9C2 Q15653	O95602
PDB IDs
Enriched GO Terms of Interacting Partners?
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