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NFKBIB and BAK1
Data Source:
BioGRID
(enzymatic study)
NFKBIB
BAK1
Description
NFKB inhibitor beta
BCL2 antagonist/killer 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytosol
Mitochondrion
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Cytosol
Integral Component Of Mitochondrial Outer Membrane
Pore Complex
Bcl-2 Family Protein Complex
BAK Complex
Molecular Function
Transcription Coactivator Activity
Protein Binding
Molecular_function
Protein Binding
Heat Shock Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein-containing Complex Binding
Metal Ion Binding
Protein Heterodimerization Activity
Chaperone Binding
BH Domain Binding
Biological Process
Transcription, DNA-templated
Signal Transduction
Cytoplasmic Sequestering Of NF-kappaB
Positive Regulation Of Transcription, DNA-templated
Cellular Response To Lipopolysaccharide
B Cell Homeostasis
B Cell Apoptotic Process
Release Of Cytochrome C From Mitochondria
Blood Vessel Remodeling
Myeloid Cell Homeostasis
B Cell Negative Selection
Apoptotic Process
Brain Development
Aging
Mitochondrial Fusion
Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Response To Fungus
Response To Mycotoxin
Response To UV-C
Establishment Or Maintenance Of Transmembrane Electrochemical Gradient
Response To Gamma Radiation
Positive Regulation Of Calcium Ion Transport Into Cytosol
Negative Regulation Of Gene Expression
Response To Organic Cyclic Compound
Viral Process
Endocrine Pancreas Development
Animal Organ Regeneration
Positive Regulation Of Protein-containing Complex Assembly
Endoplasmic Reticulum Calcium Ion Homeostasis
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Negative Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Unfolded Protein
Cellular Response To UV
Limb Morphogenesis
Response To Drug
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Fibroblast Apoptotic Process
Response To Ethanol
Positive Regulation Of Proteolysis
Regulation Of Mitochondrial Membrane Permeability
Post-embryonic Camera-type Eye Morphogenesis
Regulation Of Cell Cycle
Regulation Of Mitochondrial Membrane Potential
Vagina Development
Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Thymocyte Apoptotic Process
Cellular Response To Mechanical Stimulus
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Apoptotic Process Involved In Blood Vessel Morphogenesis
Positive Regulation Of IRE1-mediated Unfolded Protein Response
Pathways
Activation of NF-kappaB in B cells
RIP-mediated NFkB activation via ZBP1
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
TRAF6 mediated NF-kB activation
Activation and oligomerization of BAK protein
Release of apoptotic factors from the mitochondria
Drugs
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) (
28112199
)
Body mass index (
26426971
)
Chronic lymphocytic leukemia (
28165464
22700719
24292274
23770605
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
27841878
)
Eosinophil counts (
32888494
27863252
)
Eosinophil percentage of white cells (
32888494
27863252
)
Hematological parameters (
19820697
)
Lung cancer (
28604730
)
Multiple sclerosis and systolic blood pressure (pleiotropy) (
26920376
)
Neutrophil percentage of granulocytes (
27863252
)
Obesity-related traits (
23251661
)
Platelet count (
26805783
22139419
24026423
29066854
23263863
29403010
32888494
22423221
25705162
20139978
27863252
28031487
)
Platelet distribution width (
32888494
)
Plateletcrit (
32888494
27863252
)
Schizophrenia (
30285260
)
Sum eosinophil basophil counts (
27863252
)
Testicular germ cell tumor (
19483681
28604728
28604732
23666239
23666240
)
Interacting Genes
43 interacting genes:
APP
BAK1
BTBD6
BTRC
CDC25A
CHUK
CSNK2A1
CUL1
DNAJA3
ESR2
FHL3
GIT2
IKBKB
IKBKG
KPNA2
LRPPRC
MCC
MTIF2
NCOR2
NDUFB7
NFKB1
NFKB2
NFKBIA
NGFR
NKIRAS1
NKIRAS2
PDCD2
POLR1A
POLR1B
POLR1C
POLR1D
POLR1E
POLR1G
POLR2H
POLR2L
PPARG
RASAL2
REL
RELA
RXRA
SKP1
TSPAN1
VPS52
19 interacting genes:
ARHGDIA
BAX
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BID
DBN1
ERN1
HERC1
HSD17B4
HSPD1
MCL1
MFN1
NFKBIB
TP53
VDAC1
VDAC2
Entrez ID
4793
578
HPRD ID
07260
02744
Ensembl ID
ENSG00000104825
ENSG00000030110
Uniprot IDs
G5E9C2
Q15653
A0A0S2Z391
Q16611
PDB IDs
1BXL
2IMS
2IMT
2JBY
2JCN
2LP8
2M5B
2XPX
2YV6
3I1H
3QBR
4D2L
4U2U
4U2V
4UF1
5AJK
5FMI
5FMK
5VWV
5VWW
5VWX
5VWY
5VWZ
5VX0
5VX1
6ODH
6UXM
6UXN
6UXO
6UXP
6UXQ
6UXR
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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