POLR1A and NOLC1

Data Source:
HPRD (in vivo, in vitro)

		POLR1A	NOLC1
Description		RNA polymerase I subunit A	nucleolar and coiled-body phosphoprotein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome RNA Polymerase I Complex	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Cajal Body Box C/D RNP Complex Box H/ACA SnoRNP Complex
	Molecular Function	RNA Polymerase I Activity DNA Binding Chromatin Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding	DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding ATP Binding GTP Binding Transcription Factor Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Box C/D RNA Binding Box H/ACA SnoRNA Binding Protein Heterodimerization Activity Box C/D SnoRNP Complex Binding Box H/ACA SnoRNP Complex Binding
	Biological Process	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleolus	Mitotic Cell Cycle RRNA Processing Regulation Of Translation Response To Osmotic Stress Nucleolus Organization Positive Regulation Of Cell Population Proliferation Neural Crest Formation Neural Crest Cell Development Box H/ACA RNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs			Doxorubicin
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620)	Triglyceride levels ( 32203549)
Interacting Genes		10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN REL RRN3 TCF4	16 interacting genes: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B KBTBD8 MDM2 POLR1A PRKACA SRPK2 USP4 YWHAG YWHAQ
Entrez ID		25885	9221
HPRD ID		10161	03864
Ensembl ID		ENSG00000068654	ENSG00000166197
Uniprot IDs		O95602	B2RAU8 Q14978 Q96J17
PDB IDs
Enriched GO Terms of Interacting Partners?
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