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POLR1A and NOLC1
Data Source:
HPRD
(in vivo, in vitro)
POLR1A
NOLC1
Description
RNA polymerase I subunit A
nucleolar and coiled-body phosphoprotein 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Chromosome
RNA Polymerase I Complex
Fibrillar Center
Nucleoplasm
Nucleolus
Cytoplasm
Cajal Body
Box C/D RNP Complex
Box H/ACA SnoRNP Complex
Molecular Function
RNA Polymerase I Activity
DNA Binding
Chromatin Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Zinc Ion Binding
DNA Binding
DNA-binding Transcription Factor Activity
RNA Binding
Protein Binding
ATP Binding
GTP Binding
Transcription Factor Binding
Nuclear Localization Sequence Binding
Protein Domain Specific Binding
Protein-macromolecule Adaptor Activity
Box C/D RNA Binding
Box H/ACA SnoRNA Binding
Protein Heterodimerization Activity
Box C/D SnoRNP Complex Binding
Box H/ACA SnoRNP Complex Binding
Biological Process
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Positive Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Protein Localization To Nucleolus
Mitotic Cell Cycle
RRNA Processing
Regulation Of Translation
Response To Osmotic Stress
Nucleolus Organization
Positive Regulation Of Cell Population Proliferation
Neural Crest Formation
Neural Crest Cell Development
Box H/ACA RNA Metabolic Process
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Transcription, DNA-templated
Pathways
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Drugs
Doxorubicin
Diseases
GWAS
Facial emotion recognition (sad faces) (
28608620
)
Triglyceride levels (
32203549
)
Interacting Genes
10 interacting genes:
ANP32B
DYDC2
MEOX2
NFKBIB
NOLC1
POLR1E
PTEN
REL
RRN3
TCF4
16 interacting genes:
APP
CEBPB
COIL
CSNK2A1
CSNK2B
E2F4
ERG
GTF2B
KBTBD8
MDM2
POLR1A
PRKACA
SRPK2
USP4
YWHAG
YWHAQ
Entrez ID
25885
9221
HPRD ID
10161
03864
Ensembl ID
ENSG00000068654
ENSG00000166197
Uniprot IDs
O95602
B2RAU8
Q14978
Q96J17
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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