POLR1A and ANP32B

Data Source:
HPRD (in vitro)

		POLR1A	ANP32B
Description		RNA polymerase I subunit A	acidic nuclear phosphoprotein 32 family member B
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome RNA Polymerase I Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Extracellular Exosome
	Molecular Function	RNA Polymerase I Activity DNA Binding Chromatin Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding	Protein Binding Histone Binding RNA Polymerase Binding
	Biological Process	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleolus	Vasculature Development Nucleosome Assembly Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Ventricular System Development Regulation Of Apoptotic Process Negative Regulation Of Cell Differentiation Positive Regulation Of Protein Export From Nucleus Inner Ear Development Roof Of Mouth Development
Pathways		NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Facial emotion recognition (sad faces) ( 28608620)	Alopecia areata ( 25608926) Coronary artery disease ( 29212778) Eosinophil counts ( 32888494) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Serum thyroid-stimulating hormone levels ( 25436638)
Interacting Genes		10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN REL RRN3 TCF4	43 interacting genes: AIM2 APC APP AURKA BAX BCL10 BEND7 BUB1 CHAF1A CSNK2A1 DCC DNTTIP1 ELAVL1 ESR1 FAM217B FAM3A FBXW7 H2AC1 H2BC1 H3C1 H4C1 HNF4A KLF5 KPNA1 KPNA5 KPNA6 MCC MEOX2 MLH3 MYNN PMS2 POLR1A PTEN PTPN12 PTPRJ SDCBP SMAD2 SMARCD1 STK11 TLR2 UCHL5 XPO1 YAF2
Entrez ID		25885	10541
HPRD ID		10161	09803
Ensembl ID		ENSG00000068654	ENSG00000136938
Uniprot IDs		O95602	Q92688
PDB IDs			2ELL 2RR6
Enriched GO Terms of Interacting Partners?
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