NFKBIB and MTIF2

Data Source:
HPRD (in vitro)

		NFKBIB	MTIF2
Description		NFKB inhibitor beta	mitochondrial translational initiation factor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleoplasm Mitochondrion
	Molecular Function	Transcription Coactivator Activity Protein Binding	RNA Binding Translation Initiation Factor Activity GTPase Activity GTP Binding Translation Factor Activity, RNA Binding Ribosomal Small Subunit Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Cytoplasmic Sequestering Of NF-kappaB Positive Regulation Of Transcription, DNA-templated Cellular Response To Lipopolysaccharide	Regulation Of Translational Initiation Ribosome Disassembly Mitochondrial Translational Initiation
Pathways		Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TRAF6 mediated NF-kB activation	Mitochondrial translation initiation
Drugs
Diseases
GWAS			Dementia and core Alzheimer's disease neuropathologic changes ( 25188341)
Interacting Genes		43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52	3 interacting genes: HSPB1 NFKBIB TSC22D2
Entrez ID		4793	4528
HPRD ID		07260	04792
Ensembl ID		ENSG00000104825	ENSG00000085760
Uniprot IDs		G5E9C2 Q15653	P46199 Q6P1N2
PDB IDs			6GAW 6GAZ 6GB2 6RW5
Enriched GO Terms of Interacting Partners?
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