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MMP14 and FHL3
Data Source:
BioGRID
(two hybrid)
MMP14
FHL3
Description
matrix metallopeptidase 14
four and a half LIM domains 3
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Stress Fiber
Nucleus
Focal Adhesion
Z Disc
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Zinc Ion Binding
Metalloaminopeptidase Activity
Transcription Coregulator Activity
Actin Binding
Protein Binding
Metal Ion Binding
Biological Process
Skeletal System Development
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Response To Organic Cyclic Compound
Protein Processing
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Craniofacial Suture Morphogenesis
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Regulation Of Transcription, DNA-templated
Muscle Organ Development
Actin Cytoskeleton Organization
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Drugs
Marimastat
Diseases
GWAS
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
35 interacting genes:
ACAN
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CLDN1
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SPOCK1
SPOCK3
STOM
TIMP2
TIMP3
TIMP4
TMEM31
ZUP1
181 interacting genes:
A1CF
ACTB
ADAM15
ADAMTSL4
AIMP2
AMBP
ANKHD1
ARHGEF10
ARID5A
ASCL4
BARX2
C1orf94
C9orf116
CASS4
CBX8
CCDC198
CCND3
CDC25B
CDC42EP1
CDKN1A
CDKN2D
CHEK2
CLCN2
CNNM3
CNOT7
CORO1A
CREB5
CRIP3
CRYBA2
CSF1
CTBP2
CYSRT1
DCDC2B
DLGAP4
DMRT3
DUX4L9
E2F8
EFCAB12
EIF4EBP2
EPHA10
EPM2AIP1
ERBB3
EXOSC1
EXOSC5
FADS6
FAM110A
FAM126A
FAM222B
FAM71C
FAM90A1
FBXL18
FHL2
FOS
FOSL2
FOXN4
GATA1
GATA2
GCM2
GUCD1
HAPLN2
HIPK1
HOXA1
HSF2BP
HYAL2
IHO1
IKZF3
ITGA7
ITGB5
KANK2
KIDINS220
KIRREL2
KLF12
KLF3
KLF8
KPRP
KRTAP12-1
KRTAP12-2
KTI12
LASP1
LATS2
LHB
LMO2
LMO4
LNX1
LNX2
MAPK1
MED15
MMP14
MORF4L1
MPZL1
MRM3
MRPL27
MRRF
MSRB3
MTA1
MTUS2
MYBPC1
MYBPHL
MYOZ3
MYPOP
MZF1
NDUFAB1
NFKBIB
NPRL3
ODF3B
P4HA2
PAK5
PATL1
PHC2
PHF21A
PIAS1
PKP2
PLEKHF2
PLEKHG4B
POLR1H
PPIG
PPP1R32
PRR35
PRR5L
PTPN6
QKI
QRICH1
RAB40B
RAD21
RASL12
RBM42
RFX3
RFX6
RHEBL1
RSPH14
RYBP
SAP30BP
SAXO1
SBF2
SDCBP
SH3GLB2
SHE
SLAIN1
SLC25A46
SLC44A3
SLU7
SMAD2
SMAD3
SMAD4
SNRPB
SNRPC
SNRPG
SPATA8
SREBF2
SRF
SRGN
SUPT5H
TBC1D22B
THAP7
THEG
TLE5
TMEM108
TMEM14B
TMSB4X
TMX3
TOPBP1
TRAF3IP2
TRIM27
TRIP6
TRO
TSGA10IP
TTLL10
TUBA3E
TYK2
TYMSOS
UBE2I
UBE2Q1
VWC2L
WDR25
WNK1
YPEL3
ZCCHC14
ZFP36
ZNF417
ZNF512B
ZNF587
Entrez ID
4323
2275
HPRD ID
02856
09101
Ensembl ID
ENSG00000157227
ENSG00000183386
Uniprot IDs
P50281
Q13643
Q96C98
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
1WYH
2CUQ
2EHE
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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