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FHL3 and ZFP36
Data Source:
BioGRID
(two hybrid)
FHL3
ZFP36
Description
four and a half LIM domains 3
ZFP36 ring finger protein
Image
GO Annotations
Cellular Component
Stress Fiber
Nucleus
Focal Adhesion
Z Disc
Exosome (RNase Complex)
P-body
Nucleus
Cytoplasm
Cytosol
Cytoplasmic Stress Granule
CCR4-NOT Complex
RISC-loading Complex
Ribonucleoprotein Complex
Molecular Function
Transcription Coregulator Activity
Actin Binding
Protein Binding
Metal Ion Binding
DNA Binding
RNA Binding
MRNA Binding
Protein Binding
Enzyme Binding
Protein Kinase Binding
C-C Chemokine Binding
Heat Shock Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Protein-containing Complex Binding
Metal Ion Binding
RNA Polymerase Binding
14-3-3 Protein Binding
Biological Process
Regulation Of Transcription, DNA-templated
Muscle Organ Development
Actin Cytoskeleton Organization
Negative Regulation Of Transcription By RNA Polymerase II
MAPK Cascade
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Nuclear-transcribed MRNA Poly(A) Tail Shortening
MRNA Catabolic Process
Response To Wounding
Regulation Of Keratinocyte Proliferation
Viral Process
Nuclear-transcribed MRNA Catabolic Process, Deadenylation-independent Decay
Regulation Of Tumor Necrosis Factor Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Viral Transcription
MiRNA Mediated Inhibition Of Translation
P38MAPK Cascade
Response To Starvation
Regulation Of MRNA Stability
Cellular Response To Fibroblast Growth Factor Stimulus
Positive Regulation Of Fat Cell Differentiation
Regulation Of Keratinocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
MRNA Transport
Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
3'-UTR-mediated MRNA Destabilization
3'-UTR-mediated MRNA Stabilization
Cellular Response To Lipopolysaccharide
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Glucocorticoid Stimulus
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Positive Regulation Of Deadenylation-independent Decapping Of Nuclear-transcribed MRNA
Regulation Of Keratinocyte Apoptotic Process
Negative Regulation Of Polynucleotide Adenylyltransferase Activity
Positive Regulation Of Intracellular MRNA Localization
Positive Regulation Of Gene Silencing By MiRNA
Pathways
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
181 interacting genes:
A1CF
ACTB
ADAM15
ADAMTSL4
AIMP2
AMBP
ANKHD1
ARHGEF10
ARID5A
ASCL4
BARX2
C1orf94
C9orf116
CASS4
CBX8
CCDC198
CCND3
CDC25B
CDC42EP1
CDKN1A
CDKN2D
CHEK2
CLCN2
CNNM3
CNOT7
CORO1A
CREB5
CRIP3
CRYBA2
CSF1
CTBP2
CYSRT1
DCDC2B
DLGAP4
DMRT3
DUX4L9
E2F8
EFCAB12
EIF4EBP2
EPHA10
EPM2AIP1
ERBB3
EXOSC1
EXOSC5
FADS6
FAM110A
FAM126A
FAM222B
FAM71C
FAM90A1
FBXL18
FHL2
FOS
FOSL2
FOXN4
GATA1
GATA2
GCM2
GUCD1
HAPLN2
HIPK1
HOXA1
HSF2BP
HYAL2
IHO1
IKZF3
ITGA7
ITGB5
KANK2
KIDINS220
KIRREL2
KLF12
KLF3
KLF8
KPRP
KRTAP12-1
KRTAP12-2
KTI12
LASP1
LATS2
LHB
LMO2
LMO4
LNX1
LNX2
MAPK1
MED15
MMP14
MORF4L1
MPZL1
MRM3
MRPL27
MRRF
MSRB3
MTA1
MTUS2
MYBPC1
MYBPHL
MYOZ3
MYPOP
MZF1
NDUFAB1
NFKBIB
NPRL3
ODF3B
P4HA2
PAK5
PATL1
PHC2
PHF21A
PIAS1
PKP2
PLEKHF2
PLEKHG4B
POLR1H
PPIG
PPP1R32
PRR35
PRR5L
PTPN6
QKI
QRICH1
RAB40B
RAD21
RASL12
RBM42
RFX3
RFX6
RHEBL1
RSPH14
RYBP
SAP30BP
SAXO1
SBF2
SDCBP
SH3GLB2
SHE
SLAIN1
SLC25A46
SLC44A3
SLU7
SMAD2
SMAD3
SMAD4
SNRPB
SNRPC
SNRPG
SPATA8
SREBF2
SRF
SRGN
SUPT5H
TBC1D22B
THAP7
THEG
TLE5
TMEM108
TMEM14B
TMSB4X
TMX3
TOPBP1
TRAF3IP2
TRIM27
TRIP6
TRO
TSGA10IP
TTLL10
TUBA3E
TYK2
TYMSOS
UBE2I
UBE2Q1
VWC2L
WDR25
WNK1
YPEL3
ZCCHC14
ZFP36
ZNF417
ZNF512B
ZNF587
26 interacting genes:
APP
ATG16L1
CCDC85B
CDK6
DCP1B
DHX36
DNAJB1
EDC3
EXOSC6
EXOSC8
FHL3
HMGB1
HOXC9
MAPK1
MAPKAPK2
NCL
NUP214
RUNX1T1
SFN
TNF
UPF2
XRN1
YWHAB
YWHAG
YWHAH
ZDHHC17
Entrez ID
2275
7538
HPRD ID
09101
01835
Ensembl ID
ENSG00000183386
ENSG00000128016
Uniprot IDs
Q13643
Q96C98
M0QY76
P26651
PDB IDs
1WYH
2CUQ
2EHE
4J8S
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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