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MMP14 and STOM
Data Source:
BioGRID
(two hybrid)
MMP14
STOM
Description
matrix metallopeptidase 14
stomatin
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Extracellular Space
Mitochondrion
Endoplasmic Reticulum
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Vesicle
Azurophil Granule Membrane
Specific Granule Membrane
Melanosome
Membrane Raft
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Tertiary Granule Membrane
Blood Microparticle
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Zinc Ion Binding
Metalloaminopeptidase Activity
Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
RNA Polymerase Binding
Biological Process
Skeletal System Development
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Response To Organic Cyclic Compound
Protein Processing
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Craniofacial Suture Morphogenesis
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Neutrophil Degranulation
Positive Regulation By Host Of Viral Genome Replication
Positive Regulation Of Protein Targeting To Membrane
Regulation Of Acid-sensing Ion Channel Activity
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Stimuli-sensing channels
Neutrophil degranulation
Drugs
Marimastat
Diseases
Hereditary stomatocytosis (HSt); Dehydrated hereditary stomatocytosis (DHS); Overhydrated hereditary stomatocytosis (OHS); Familial pseudohyperkalemia (FP)
GWAS
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
35 interacting genes:
ACAN
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CLDN1
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SPOCK1
SPOCK3
STOM
TIMP2
TIMP3
TIMP4
TMEM31
ZUP1
81 interacting genes:
AIG1
APOA2
ASIC1
ASIC2
ASIC3
ATP1B3
ATP6V0B
ATP6V0C
BCL2L2
BNIP1
C2
C3orf52
CFHR5
CHST1
CLDN19
CLRN2
CMTM5
CNIH3
CTXN3
CYB5B
CYB5R3
DAGLA
DVL3
EMP1
ERG28
FAXDC2
FUNDC2
GIMAP1
GIMAP5
GPR25
GPR37L1
GRM2
HMOX2
KCNK1
KTN1
LANCL1
LNPEP
MGLL
MMP14
NKG7
ORMDL1
PEDS1-UBE2V1
PEMT
PGA4
PMP22
PTCH1
RPL13A
RPRM
RTP2
RUVBL1
RUVBL2
SCD
SELENOK
SERP2
SFT2D1
SFT2D2
SFXN1
SFXN5
SLC2A1
SLC35B4
SMCO4
STX6
TECR
THSD7B
TMEM109
TMEM120B
TMEM140
TMEM14B
TMEM203
TMEM208
TMEM254
TMEM60
TMEM86B
TMEM98
TMPO
TNF
TNFRSF10C
TSPO2
VAMP4
WFDC2
YIPF6
Entrez ID
4323
2040
HPRD ID
02856
00585
Ensembl ID
ENSG00000157227
ENSG00000148175
Uniprot IDs
P50281
A0A024R882
F8VSL7
P27105
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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