FHL3 and MTA1

Data Source:
BioGRID (two hybrid)

		FHL3	MTA1
Description		four and a half LIM domains 3	metastasis associated 1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Focal Adhesion Z Disc	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Microtubule NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Muscle Organ Development Actin Cytoskeleton Organization	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Signal Transduction Response To Ionizing Radiation Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Autoubiquitination
Pathways			HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Heel bone mineral density ( 30598549)
Interacting Genes		181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 C9orf116 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM126A FAM222B FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 ODF3B P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PPP1R32 PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 THEG TLE5 TMEM108 TMEM14B TMSB4X TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587	45 interacting genes: BCL11A BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MBD3L2 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SUMO2 TEX11 TP53 TRIM25 UBE2I
Entrez ID		2275	9112
HPRD ID		09101	04633
Ensembl ID		ENSG00000183386	ENSG00000182979
Uniprot IDs		Q13643 Q96C98	Q13330 Q9BRL8
PDB IDs		1WYH 2CUQ 2EHE	4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16
Enriched GO Terms of Interacting Partners?
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