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MMP14 and KASH5
Data Source:
BioGRID
(two hybrid)
MMP14
KASH5
Description
matrix metallopeptidase 14
KASH domain containing 5
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Chromosome, Telomeric Region
Lateral Element
Nuclear Outer Membrane
Integral Component Of Membrane
Meiotic Nuclear Membrane Microtubule Tethering Complex
Meiotic Spindle Pole
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Zinc Ion Binding
Metalloaminopeptidase Activity
Protein Binding
Identical Protein Binding
Dynein Complex Binding
Biological Process
Skeletal System Development
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Response To Organic Cyclic Compound
Protein Processing
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Craniofacial Suture Morphogenesis
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Double-strand Break Repair Via Homologous Recombination
Actin Filament Organization
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Telomere Localization
Oogenesis
Spindle Assembly
Spindle Localization
Microtubule Cytoskeleton Organization Involved In Homologous Chromosome Segregation
Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Drugs
Marimastat
Diseases
GWAS
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
35 interacting genes:
ACAN
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CLDN1
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SPOCK1
SPOCK3
STOM
TIMP2
TIMP3
TIMP4
TMEM31
ZUP1
112 interacting genes:
ABHD1
ADIPOQ
ANKRD46
ATF7
BAG5
BCL2L2
BET1
C14orf180
CCDC120
CCDC87
CDC73
CDKL3
CIB3
CLDN8
CMTM5
CRABP2
CTXN3
CWF19L2
CXCL16
CXCL9
CYBC1
DERL1
DNAJC30
EFNA5
EMD
FAM161A
FAM241B
FAM50B
FAM90A1
FATE1
FIS1
FRA10AC1
FTCD
FXYD3
GABARAPL2
GALNT2
GIMAP5
GOSR2
GPATCH4
GPR25
HMOX1
ITGAM
ITM2B
JAGN1
KDM1A
LARP1
LAT
LENG1
LHFPL5
LMNA
LRCH4
MALL
MARCHF2
MFSD5
MMP14
MOSPD3
MS4A1
MTX2
NRIP3
NSG1
NTAQ1
OLFM4
PDGFRA
PGAP2
PGRMC1
PIGU
PLP2
PLPP6
PPP1R18
RIPPLY2
RNF146
RSPH14
RSRC2
RTP2
SENP2
SERP2
SGTA
SHMT2
SLC30A2
SLC35B4
SLC41A1
SLC41A2
SLC5A4
SLN
SMCO4
SNAP47
STBD1
STX12
STX5
TCF25
TMEM11
TMEM147
TMEM14C
TMEM19
TMEM199
TMEM41A
TMEM86A
TMPRSS4
TNF
TRAF3IP3
TRARG1
TSHZ3
TTC23
UPK1B
UPK2
VAMP1
VAMP2
VAMP4
VTI1B
ZC2HC1C
ZFPL1
ZNF250
Entrez ID
4323
147872
HPRD ID
02856
08134
Ensembl ID
ENSG00000157227
ENSG00000161609
Uniprot IDs
P50281
Q8N6L0
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
6R2I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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