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MMP14 and F11R
Data Source:
BioGRID
(two hybrid)
MMP14
F11R
Description
matrix metallopeptidase 14
F11 receptor
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Plasma Membrane
Cell-cell Junction
Bicellular Tight Junction
Integral Component Of Membrane
Cell Junction
Cytoplasmic Vesicle
Protein-containing Complex
Slit Diaphragm
Extracellular Exosome
Tight Junction
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Zinc Ion Binding
Metalloaminopeptidase Activity
Virus Receptor Activity
Integrin Binding
Protein Binding
PDZ Domain Binding
Protein Homodimerization Activity
Cadherin Binding
Biological Process
Skeletal System Development
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Response To Organic Cyclic Compound
Protein Processing
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Craniofacial Suture Morphogenesis
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Regulation Of Cytokine Production
Inflammatory Response
Leukocyte Cell-cell Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cell Shape
Response To Radiation
Extracellular Matrix Organization
Actomyosin Structure Organization
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of GTPase Activity
Positive Regulation Of Rho Protein Signal Transduction
Maintenance Of Blood-brain Barrier
Memory T Cell Extravasation
Positive Regulation Of GTPase Activity
Positive Regulation Of Blood Pressure
Viral Entry Into Host Cell
Intestinal Absorption
Leukocyte Migration
Regulation Of Cytoskeleton Organization
Negative Regulation Of Stress Fiber Assembly
Bicellular Tight Junction Assembly
Cellular Response To Mechanical Stimulus
Protein Localization To Plasma Membrane
Establishment Of Endothelial Intestinal Barrier
Regulation Of Membrane Permeability
Cell-cell Adhesion
Positive Regulation Of Platelet Aggregation
Protein Localization To Bicellular Tight Junction
Positive Regulation Of Establishment Of Endothelial Barrier
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Bicellular Tight Junction Assembly
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Cell surface interactions at the vascular wall
Integrin cell surface interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Drugs
Marimastat
Diseases
GWAS
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Inflammatory bowel disease (
23128233
)
Night sleep phenotypes (
27126917
)
Interacting Genes
35 interacting genes:
ACAN
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CLDN1
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SPOCK1
SPOCK3
STOM
TIMP2
TIMP3
TIMP4
TMEM31
ZUP1
30 interacting genes:
AFDN
ASIP
BDNF
CAMLG
CASK
CGN
CSNK2A1
F2RL2
ITGAL
JAGN1
MARCHF2
MMP14
MPDZ
MYADM
PARD3
PEX19
PGAP2
PICK1
PRKCA
PTPRB
RABAC1
SGTA
SLC30A2
SLC35A1
SNAP47
STRIT1
TJP1
TMEM100
TMEM147
TMEM86B
Entrez ID
4323
50848
HPRD ID
02856
12038
Ensembl ID
ENSG00000157227
ENSG00000158769
Uniprot IDs
P50281
Q6FIB4
Q9Y624
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
1NBQ
3EOY
3TSZ
4ODB
Enriched GO Terms of Interacting Partners
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