FHL3 and TOPBP1

Data Source:
BioGRID (two hybrid)

		FHL3	TOPBP1
Description		four and a half LIM domains 3	DNA topoisomerase II binding protein 1
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GO Annotations	Cellular Component	Stress Fiber Nucleus Focal Adhesion Z Disc	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Coregulator Activity Actin Binding Protein Binding Metal Ion Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Muscle Organ Development Actin Cytoskeleton Organization	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778 33020668) Pulse pressure ( 30578418)	Iron status biomarkers ( 19084217)
Interacting Genes		181 interacting genes: A1CF ACTB ADAM15 ADAMTSL4 AIMP2 AMBP ANKHD1 ARHGEF10 ARID5A ASCL4 BARX2 C1orf94 C9orf116 CASS4 CBX8 CCDC198 CCND3 CDC25B CDC42EP1 CDKN1A CDKN2D CHEK2 CLCN2 CNNM3 CNOT7 CORO1A CREB5 CRIP3 CRYBA2 CSF1 CTBP2 CYSRT1 DCDC2B DLGAP4 DMRT3 DUX4L9 E2F8 EFCAB12 EIF4EBP2 EPHA10 EPM2AIP1 ERBB3 EXOSC1 EXOSC5 FADS6 FAM110A FAM126A FAM222B FAM71C FAM90A1 FBXL18 FHL2 FOS FOSL2 FOXN4 GATA1 GATA2 GCM2 GUCD1 HAPLN2 HIPK1 HOXA1 HSF2BP HYAL2 IHO1 IKZF3 ITGA7 ITGB5 KANK2 KIDINS220 KIRREL2 KLF12 KLF3 KLF8 KPRP KRTAP12-1 KRTAP12-2 KTI12 LASP1 LATS2 LHB LMO2 LMO4 LNX1 LNX2 MAPK1 MED15 MMP14 MORF4L1 MPZL1 MRM3 MRPL27 MRRF MSRB3 MTA1 MTUS2 MYBPC1 MYBPHL MYOZ3 MYPOP MZF1 NDUFAB1 NFKBIB NPRL3 ODF3B P4HA2 PAK5 PATL1 PHC2 PHF21A PIAS1 PKP2 PLEKHF2 PLEKHG4B POLR1H PPIG PPP1R32 PRR35 PRR5L PTPN6 QKI QRICH1 RAB40B RAD21 RASL12 RBM42 RFX3 RFX6 RHEBL1 RSPH14 RYBP SAP30BP SAXO1 SBF2 SDCBP SH3GLB2 SHE SLAIN1 SLC25A46 SLC44A3 SLU7 SMAD2 SMAD3 SMAD4 SNRPB SNRPC SNRPG SPATA8 SREBF2 SRF SRGN SUPT5H TBC1D22B THAP7 THEG TLE5 TMEM108 TMEM14B TMSB4X TMX3 TOPBP1 TRAF3IP2 TRIM27 TRIP6 TRO TSGA10IP TTLL10 TUBA3E TYK2 TYMSOS UBE2I UBE2Q1 VWC2L WDR25 WNK1 YPEL3 ZCCHC14 ZFP36 ZNF417 ZNF512B ZNF587	32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17
Entrez ID		2275	11073
HPRD ID		09101	09678
Ensembl ID		ENSG00000183386	ENSG00000163781
Uniprot IDs		Q13643 Q96C98	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		1WYH 2CUQ 2EHE	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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