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MMP14 and ZUP1
Data Source:
BioGRID
(two hybrid)
MMP14
ZUP1
Description
matrix metallopeptidase 14
zinc finger containing ubiquitin peptidase 1
Image
GO Annotations
Cellular Component
Extracellular Space
Nucleus
Cytoplasm
Golgi Lumen
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Extracellular Matrix
Cytoplasmic Vesicle
Melanosome
Macropinosome
Intermediate Filament Cytoskeleton
Nucleus
Cytoplasm
Molecular Function
Endopeptidase Activity
Metalloendopeptidase Activity
Integrin Binding
Protein Binding
Zinc Ion Binding
Metalloaminopeptidase Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Metal Ion Binding
Biological Process
Skeletal System Development
Angiogenesis
Ovarian Follicle Development
Response To Hypoxia
Endothelial Cell Proliferation
Endochondral Ossification
Proteolysis
Response To Oxidative Stress
Male Gonad Development
Response To Mechanical Stimulus
Positive Regulation Of Myotube Differentiation
Positive Regulation Of Protein Processing
Response To Organic Cyclic Compound
Protein Processing
Extracellular Matrix Disassembly
Extracellular Matrix Organization
Positive Regulation Of Cell Growth
Lung Development
Positive Regulation Of Cell Migration
Collagen Catabolic Process
Zymogen Activation
Endodermal Cell Differentiation
Chondrocyte Proliferation
Astrocyte Cell Migration
Response To Estrogen
Positive Regulation Of B Cell Differentiation
Negative Regulation Of Notch Signaling Pathway
Embryonic Cranial Skeleton Morphogenesis
Branching Morphogenesis Of An Epithelial Tube
Tissue Remodeling
Cell Motility
Negative Regulation Of Focal Adhesion Assembly
Head Development
Craniofacial Suture Morphogenesis
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macrophage Migration
Response To Odorant
Proteolysis
Regulation Of Gene Expression
Protein Phosphopantetheinylation
Pathways
Collagen degradation
Collagen degradation
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Drugs
Marimastat
Diseases
GWAS
Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment (
32472697
)
Diastolic blood pressure (
30224653
)
Dupuytren's disease (
28886342
)
Heel bone mineral density (
30598549
28869591
)
Prostate cancer (
29892016
)
Waist-to-hip ratio adjusted for BMI (additive genetic model) (
30778226
)
Interacting Genes
35 interacting genes:
ACAN
ADI1
AQP6
BCAR1
C1QBP
CAV1
CCL7
CLDN1
EBP
ELOVL4
F11R
F12
FHL3
FURIN
HSD17B13
ITGAV
KASH5
KISS1
LRP1
LUM
MMP13
MMP2
MMP3
MSMO1
PLLP
RRAD
SDC1
SPOCK1
SPOCK3
STOM
TIMP2
TIMP3
TIMP4
TMEM31
ZUP1
8 interacting genes:
ARHGAP45
CDKN2A
CLN8
MMP14
PRMT5
RPS21
SHCBP1
UBC
Entrez ID
4323
221302
HPRD ID
02856
12840
Ensembl ID
ENSG00000157227
ENSG00000153975
Uniprot IDs
P50281
A0A0S2Z644
Q96AP4
PDB IDs
1BQQ
1BUV
2MQS
3C7X
3MA2
3X23
4P3C
4P3D
4QXU
5H0U
6CLZ
6CM1
6EI1
6FGE
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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