IKBKB and E2F4

Data Source:
BioGRID (enzymatic study)

		IKBKB	E2F4
Description		inhibitor of nuclear factor kappa B kinase subunit beta	E2F transcription factor 4
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transferrin Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Cortical Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Myosin-light-chain-phosphatase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Centriole Assembly Multi-ciliated Epithelial Cell Differentiation
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry
Drugs		Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib
Diseases
GWAS			Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		87 interacting genes: ACVR1 AKT1 AURKA CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB	31 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1
Entrez ID		3551	1874
HPRD ID		04462	02806
Ensembl ID		ENSG00000104365	ENSG00000205250
Uniprot IDs		O14920	Q16254
PDB IDs		3BRT 3BRV 4E3C 4KIK	1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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