E2F4 and TRRAP

Data Source:
HPRD (in vivo)

		E2F4	TRRAP
Description		E2F transcription factor 4	transformation/transcription domain associated protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm RNA Polymerase II Transcription Regulator Complex	SAGA Complex PCAF Complex Swr1 Complex Nucleus Nucleoplasm Golgi Apparatus STAGA Complex Transcription Factor TFTC Complex NuA4 Histone Acetyltransferase Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Domain Specific Binding Protein Dimerization Activity Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	Transcription Coregulator Activity Protein Binding Kinase Activity
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Epithelial Cell Development Regulation Of Transcription By RNA Polymerase II Cell Volume Homeostasis DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Blood Circulation Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Motile Cilium Assembly Positive Regulation Of Transcription By RNA Polymerase II Centriole Assembly Multi-ciliated Epithelial Cell Differentiation	DNA Repair Regulation Of Transcription, DNA-templated Phosphorylation Histone Acetylation Histone Deubiquitination Protein Deubiquitination Histone H4 Acetylation Histone H2A Acetylation Beta-catenin-TCF Complex Assembly
Pathways		Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry	Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex HATs acetylate histones Ub-specific processing proteases
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Hemoglobin levels ( 32327693) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		31 interacting genes: AP3S2 ARID3A ATAD2 BRCA1 CHMP2A CHUK FHL2 HCFC1 ID3 IKBKB KAT5 LRRK2 MFHAS1 MGA NDN NOLC1 PCM1 PIN1 POLR1D RB1 RBL1 RBL2 RNF144A RYBP SMAD2 SMAD3 SPIB TFDP1 TFDP2 TRRAP XPO1	18 interacting genes: ACTL6A ATXN7 AURKA BRCA1 BRD8 CDC42 CTNNB1 E2F1 E2F4 EP400 ESR1 KAT2A MAX MRGBP MYC PYGO2 SKP1 TCF3
Entrez ID		1874	8295
HPRD ID		02806	04310
Ensembl ID		ENSG00000205250	ENSG00000196367
Uniprot IDs		Q16254	Q9Y4A5
PDB IDs		1CF7 5TUU
Enriched GO Terms of Interacting Partners?
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