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E2F4 and SPIB
Data Source:
BioGRID
(two hybrid)
E2F4
SPIB
Description
E2F transcription factor 4
Spi-B transcription factor
Image
No pdb structure
GO Annotations
Cellular Component
Chromatin
Nucleoplasm
Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Chromatin
Nucleus
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Protein Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Epithelial Cell Development
Regulation Of Transcription By RNA Polymerase II
Cell Volume Homeostasis
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Blood Circulation
Animal Organ Morphogenesis
Regulation Of Cell Population Proliferation
Motile Cilium Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Centriole Assembly
Multi-ciliated Epithelial Cell Differentiation
Regulation Of Transcription By RNA Polymerase II
Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Primary biliary cholangitis (
21399635
20639880
26394269
)
Systolic blood pressure (
30224653
)
Interacting Genes
31 interacting genes:
AP3S2
ARID3A
ATAD2
BRCA1
CHMP2A
CHUK
FHL2
HCFC1
ID3
IKBKB
KAT5
LRRK2
MFHAS1
MGA
NDN
NOLC1
PCM1
PIN1
POLR1D
RB1
RBL1
RBL2
RNF144A
RYBP
SMAD2
SMAD3
SPIB
TFDP1
TFDP2
TRRAP
XPO1
19 interacting genes:
CEBPB
CREBBP
CSNK2A1
CSNK2A2
E2F1
E2F2
E2F3
E2F4
EP300
GATA1
IRF4
JUN
MAPK3
MAPK8
RB1
SPI1
SSB
TBP
TMEM37
Entrez ID
1874
6689
HPRD ID
02806
06007
Ensembl ID
ENSG00000205250
ENSG00000269404
Uniprot IDs
Q16254
A0A024R4I5
Q01892
PDB IDs
1CF7
5TUU
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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