IKBKB and PRKCE

Data Source:
BioGRID (enzymatic study)

		IKBKB	PRKCE
Description		inhibitor of nuclear factor kappa B kinase subunit beta	protein kinase C epsilon
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Cell Periphery
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transferrin Receptor Binding	Actin Monomer Binding Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Calcium-independent Protein Kinase C Activity Protein Binding ATP Binding Enzyme Activator Activity Enzyme Binding Signaling Receptor Activator Activity Ethanol Binding Metal Ion Binding 14-3-3 Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Cortical Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Myosin-light-chain-phosphatase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly	Macrophage Activation Involved In Immune Response Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Fibroblast Migration Positive Regulation Of Cell-substrate Adhesion Peptidyl-serine Phosphorylation Platelet Activation Positive Regulation Of Actin Filament Polymerization Negative Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Insulin Secretion Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Cytokinesis Intracellular Signal Transduction Locomotory Exploration Behavior TRAM-dependent Toll-like Receptor 4 Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Morphine Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Lipid Catabolic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell Division Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Mucus Secretion Cellular Response To Ethanol Cellular Response To Prostaglandin E Stimulus Cellular Response To Hypoxia Positive Regulation Of Wound Healing Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Positive Regulation Of Cellular Glucuronidation
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis G alpha (z) signalling events
Drugs		Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib	Tamoxifen KAI-1455 Bryostatin 1 Fostamatinib
Diseases
GWAS			Body mass index ( 28552196) Carotenoid levels (alpha-carotene) ( 28002826) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Coronary artery disease ( 29212778 33020668) Corpus callosum posterior volume ( 31530798) Craniofacial microsomia ( 26853712) Diastolic blood pressure ( 28135244 30578418) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Hematocrit ( 29403010 32888494 28453575 27863252 28017375 19862010) Hematological and biochemical traits ( 31902109 20139978) Hemoglobin ( 29403010 32888494 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) High light scatter reticulocyte count ( 32888494 27863252) LDL cholesterol ( 30275531) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) Pathological gambling ( 27315593) Platelet count ( 32888494) Plateletcrit ( 32888494) Premature menopause in childhood cancer survivors ( 29432556) Pulse pressure ( 28135244 27841878 30578418) Red blood cell count ( 29403010 32888494 20139978 27863252 28017375) Red blood cell traits ( 23446634 23222517) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Reticulocyte count ( 32888494) Suicide risk ( 21041247) Systolic blood pressure ( 30578418) Total cholesterol levels ( 30275531) Triiodothyronine levels ( 30824882) Two-hour glucose in pregnancy (gestational week 30-32) ( 30324795) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Weight ( 28552196) White blood cell count ( 32888494)
Interacting Genes		87 interacting genes: ACVR1 AKT1 AURKA CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB	59 interacting genes: ACTA1 ACTC1 ADAP1 AFAP1 AKAP9 ATF2 BRAF BTK CFTR CHAT CNN1 COPB1 COPB2 DSP EGFR ELAVL1 FYN GAD1 GAD2 GJA1 GNA12 GNA13 GRIN1 GRIN2D GRM5 H1-1 HK2 IKBKB ITGB1 ITGB2 KRT1 KRT18 MAP4K4 MAPK1 MAPK3 MAPT MARK2 MYH2 NANOG NUMB OPRD1 PDLIM5 PDPK1 PECAM1 PIK3CB PPP1R14A PRKD1 RACK1 RAD9A RAF1 RASGRP3 RPS6KB2 SLC25A4 SLC4A3 SNCA SRC TIAM1 TRPV1 VDAC1
Entrez ID		3551	5581
HPRD ID		04462	01500
Ensembl ID		ENSG00000104365	ENSG00000171132
Uniprot IDs		O14920	L7RTI5 Q02156
PDB IDs		3BRT 3BRV 4E3C 4KIK	2WH0 5LIH
Enriched GO Terms of Interacting Partners?
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