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E2F4 and CHUK
Data Source:
BioGRID
(enzymatic study)
E2F4
CHUK
Description
E2F transcription factor 4
component of inhibitor of nuclear factor kappa B kinase complex
Image
GO Annotations
Cellular Component
Chromatin
Nucleoplasm
Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Epithelial Cell Development
Regulation Of Transcription By RNA Polymerase II
Cell Volume Homeostasis
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Blood Circulation
Animal Organ Morphogenesis
Regulation Of Cell Population Proliferation
Motile Cilium Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Centriole Assembly
Multi-ciliated Epithelial Cell Differentiation
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Skeletal Muscle Contraction
Protein Phosphorylation
Inflammatory Response
Immune Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Rho Protein Signal Transduction
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Reactive Oxygen Species
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Response To Drug
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Stress-activated MAPK Cascade
Response To Cholecystokinin
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs
Aminosalicylic acid
Mesalazine
Sulfasalazine
Acetylcysteine
Diseases
Cocoon syndrome
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Type 2 diabetes (
30054458
)
Interacting Genes
31 interacting genes:
AP3S2
ARID3A
ATAD2
BRCA1
CHMP2A
CHUK
FHL2
HCFC1
ID3
IKBKB
KAT5
LRRK2
MFHAS1
MGA
NDN
NOLC1
PCM1
PIN1
POLR1D
RB1
RBL1
RBL2
RNF144A
RYBP
SMAD2
SMAD3
SPIB
TFDP1
TFDP2
TRRAP
XPO1
81 interacting genes:
AKT1
AKT2
AMBRA1
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
COPS5
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C14
HSP90AA1
HSP90AB1
HTT
IFIT5
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
UBC
UBE2E3
UBE2I
UBE2N
Entrez ID
1874
1147
HPRD ID
02806
02811
Ensembl ID
ENSG00000205250
ENSG00000213341
Uniprot IDs
Q16254
O15111
PDB IDs
1CF7
5TUU
3BRT
5EBZ
5TQW
5TQX
5TQY
Enriched GO Terms of Interacting Partners
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