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E2F4 and ID3
Data Source:
BioGRID
(two hybrid)
E2F4
ID3
Description
E2F transcription factor 4
inhibitor of DNA binding 3, HLH protein
Image
GO Annotations
Cellular Component
Chromatin
Nucleoplasm
Cytoplasm
RNA Polymerase II Transcription Regulator Complex
Nucleus
Cytoplasm
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
Protein Dimerization Activity
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Protein Binding
Transcription Factor Binding
Protein Domain Specific Binding
Protein Dimerization Activity
Transcription Regulator Activity
Transcription Regulator Inhibitor Activity
Leptomycin B Binding
Biological Process
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Epithelial Cell Development
Regulation Of Transcription By RNA Polymerase II
Cell Volume Homeostasis
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Blood Circulation
Animal Organ Morphogenesis
Regulation Of Cell Population Proliferation
Motile Cilium Assembly
Positive Regulation Of Transcription By RNA Polymerase II
Centriole Assembly
Multi-ciliated Epithelial Cell Differentiation
Negative Regulation Of Transcription By RNA Polymerase II
Metanephros Development
Regulation Of DNA Replication
Multicellular Organism Development
Central Nervous System Development
Heart Development
Muscle Organ Development
Response To Wounding
Positive Regulation Of Gene Expression
Cell Differentiation
Neuron Differentiation
Epithelial Cell Differentiation
Notochord Development
Circadian Regulation Of Gene Expression
Odontogenesis
Positive Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Myoblast Differentiation
Negative Regulation Of Osteoblast Differentiation
Negative Regulation Of Transcription, DNA-templated
Regulation Of Cell Cycle
Cellular Response To Leptomycin B
Pathways
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by DREAM complex
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
G1/S-Specific Transcription
G1/S-Specific Transcription
Cyclin D associated events in G1
Cyclin A:Cdk2-associated events at S phase entry
NGF-stimulated transcription
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
31 interacting genes:
AP3S2
ARID3A
ATAD2
BRCA1
CHMP2A
CHUK
FHL2
HCFC1
ID3
IKBKB
KAT5
LRRK2
MFHAS1
MGA
NDN
NOLC1
PCM1
PIN1
POLR1D
RB1
RBL1
RBL2
RNF144A
RYBP
SMAD2
SMAD3
SPIB
TFDP1
TFDP2
TRRAP
XPO1
49 interacting genes:
ADD1
ANKS1A
ATF3
BOLA2
BOLA2B
C22orf39
CBFA2T2
CDK2
CNOT3
CREB5
CSK
E2F4
ELK1
ELK4
FAM74A1
FHL2
FRS3
GATA4
GNB2
GTF2A1L
GUCD1
HES1
HOXA1
ID4
IFI16
IKBKG
KAT5
KRTAP26-1
LMO4
MLX
MSGN1
MYF5
MYF6
MYOD1
MYOG
PAX5
PRDM14
PUF60
RND1
RUNX1T1
SAP30
SDCBP
SREBF1
TCF12
TCF3
TCF4
ZNF3
ZNF408
ZNF626
Entrez ID
1874
3399
HPRD ID
02806
02608
Ensembl ID
ENSG00000205250
ENSG00000117318
Uniprot IDs
Q16254
Q02535
PDB IDs
1CF7
5TUU
2LFH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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