IKBKB and EIF2AK2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		IKBKB	EIF2AK2
Description		inhibitor of nuclear factor kappa B kinase subunit beta	eukaryotic translation initiation factor 2 alpha kinase 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft	Nucleus Cytoplasm Cytosol Ribosome Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity Transferrin Receptor Binding	RNA Binding Double-stranded RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Regulator Activity Identical Protein Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Cortical Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Myosin-light-chain-phosphatase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly	Activation Of MAPKK Activity Positive Regulation Of Cytokine Production Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Response To Virus Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-tyrosine Phosphorylation Mitigation Of Host Immune Response By Virus Positive Regulation Of Chemokine Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Cellular Response To Amino Acid Starvation Response To Interferon-alpha Regulation Of Phosphoprotein Phosphatase Activity Negative Regulation Of Viral Genome Replication Innate Immune Response Protein Autophosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Hematopoietic Progenitor Cell Differentiation Regulation Of Hematopoietic Stem Cell Proliferation Regulation Of Hematopoietic Stem Cell Differentiation
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	ISG15 antiviral mechanism Inhibition of PKR
Drugs		Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine Ertiprotafib Fostamatinib	Fostamatinib
Diseases
GWAS			Glucose homeostasis traits ( 25524916) Platelet count ( 32888494)
Interacting Genes		87 interacting genes: ACVR1 AKT1 AURKA CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SASH1 SQSTM1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB	124 interacting genes: ADARB1 CASP3 CASP7 CASP8 CDC42 CHUK DHX58 DHX9 DICER1 DNAJC3 EDC4 EIF2A EIF2S1 EIF6 ELF2 FTSJ3 H2AC20 H2AC4 HSP90AA1 HSPA1A IKBKB IL7R ILF2 ILF3 JAK1 MAP3K5 MAP3K7 METAP2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MOV10 NFKBIA NPM1 PDGFRB PPP1CA PPP1CC PPP2R5A PRKRA PRKRIP1 PTGES3 RAC1 STAT1 STAT3 STRBP SUMO1 TAB2 TARBP2 THAP12 TIRAP TOLLIP TP53 TYK2 UBE2I ZNF346
Entrez ID		3551	5610
HPRD ID		04462	01468
Ensembl ID		ENSG00000104365	ENSG00000055332
Uniprot IDs		O14920	P19525 Q8IW76
PDB IDs		3BRT 3BRV 4E3C 4KIK	1QU6 2A19 2A1A 3UIU 6D3K 6D3L
Enriched GO Terms of Interacting Partners?
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