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IKBKB and EIF2AK3
Data Source:
HPRD
(in vitro, in vivo)
IKBKB
EIF2AK3
Description
inhibitor of nuclear factor kappa B kinase subunit beta
eukaryotic translation initiation factor 2 alpha kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Membrane Raft
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Scaffold Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Transferrin Receptor Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Eukaryotic Translation Initiation Factor 2alpha Kinase Activity
Protein Binding
ATP Binding
Enzyme Binding
Protein Phosphatase Binding
Identical Protein Binding
Hsp90 Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Protein Phosphorylation
Inflammatory Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Response To Virus
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Viral Process
Peptidyl-serine Phosphorylation
Cortical Actin Cytoskeleton Organization
Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Myosin-light-chain-phosphatase Activity
TRIF-dependent Toll-like Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Regulation Of Phosphorylation
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Cellular Response To Tumor Necrosis Factor
Protein Localization To Plasma Membrane
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Skeletal System Development
Ossification
Angiogenesis
Chondrocyte Development
Protein Phosphorylation
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
ER Overload Response
Endoplasmic Reticulum Organization
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Gene Expression
Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation
Negative Regulation Of Translation
Peptidyl-serine Phosphorylation
Calcium-mediated Signaling
Bone Mineralization
Endoplasmic Reticulum Unfolded Protein Response
Endocrine Pancreas Development
Negative Regulation Of Myelination
Negative Regulation Of Translational Initiation In Response To Stress
Cellular Response To Amino Acid Starvation
Response To Endoplasmic Reticulum Stress
EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Insulin-like Growth Factor Receptor Signaling Pathway
Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation
Cellular Response To Cold
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway
Response To Manganese-induced Endoplasmic Reticulum Stress
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
Downstream TCR signaling
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
CLEC7A (Dectin-1) signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PERK regulates gene expression
Drugs
Mesalazine
Sulfasalazine
Acetylsalicylic acid
Auranofin
Arsenic trioxide
MLN0415
Acetylcysteine
Ertiprotafib
Fostamatinib
Diseases
Wolcott-Rallison syndrome; SED, Wolcott-Rallison type
Permanent neonatal diabetes mellitus (PNDM)
GWAS
Adverse response to drug (
30420678
)
Appendicular lean mass (
33097823
)
Chronotype (
30696823
)
Height (
20881960
25282103
25429064
31562340
)
Progressive supranuclear palsy (
21685912
)
Interacting Genes
87 interacting genes:
ACVR1
AKT1
AURKA
CASP8
CCAR2
CDC37
CFLAR
CHUK
COPS3
COPS4
CSF2RA
CSF2RB
CTNNB1
CUEDC2
E2F4
EIF2AK2
EIF2AK3
ELP1
FAF1
FANCA
FOXO3
GLI1
HSP90AA1
HSP90AB1
HTT
IKBKG
IRS1
JUN
KLHL21
MAP3K1
MAP3K11
MAP3K13
MAP3K14
MAP3K3
MAP3K7
MAVS
MTDH
NAA20
NCOA3
NEDD4L
NFKB1
NFKB2
NFKBIA
NFKBIB
NR2C2
PEBP1
PELI1
PLK1
PPARG
PPM1B
PPP2R3C
PRKCA
PRKCB
PRKCD
PRKCE
PRKCQ
PRKCZ
PRKDC
RELA
RICTOR
RIPK1
ROCK1
SASH1
SQSTM1
SRC
STAP2
TAB2
TANK
TBK1
TFAP2C
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TP73
TRAF1
TRAF2
TRAF3IP2
TRIM21
TRIM27
TRPC4AP
TSC1
TWIST1
UBB
UBC
VHL
YWHAB
6 interacting genes:
DNAJC3
EIF2S1
HSP90AA1
HSPA5
IKBKB
NFE2L2
Entrez ID
3551
9451
HPRD ID
04462
04942
Ensembl ID
ENSG00000104365
ENSG00000172071
Uniprot IDs
O14920
B3KY45
Q68DI6
Q9NZJ5
PDB IDs
3BRT
3BRV
4E3C
4KIK
4G31
4G34
4M7I
4X7H
4X7J
4X7K
4X7L
4X7N
4X7O
4YZS
5SV7
Enriched GO Terms of Interacting Partners
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