PFN2 and CCDC113

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	CCDC113
Description		profilin 2	coiled-coil domain containing 113
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome	Axoneme Protein-containing Complex Centriolar Satellite Ciliary Basal Body
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	Protein Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Cilium Assembly
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Primary biliary cholangitis ( 28425483) Systemic lupus erythematosus ( 28714469)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	6 interacting genes: GIT1 HAP1 HSF2BP IMMT PFN2 SMYD1
Entrez ID		5217	29070
HPRD ID		01451	07121
Ensembl ID		ENSG00000070087	ENSG00000103021
Uniprot IDs		P35080	Q9H0I3
PDB IDs		1D1J
Enriched GO Terms of Interacting Partners?
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