PFN2 and PLAUR

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	PLAUR
Description		profilin 2	plasminogen activator, urokinase receptor
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome	Extracellular Region Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Specific Granule Membrane
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	Signaling Receptor Binding Protein Binding Enzyme Binding Protein Domain Specific Binding Urokinase Plasminogen Activator Receptor Activity Signaling Receptor Activity
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Positive Regulation Of Protein Phosphorylation Chemotaxis Signal Transduction Blood Coagulation Regulation Of Proteolysis Positive Regulation Of Homotypic Cell-cell Adhesion Urokinase Plasminogen Activator Signaling Pathway Fibrinolysis Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of DNA Binding Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	Attachment of GPI anchor to uPAR Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Triglyme Pentaglyme	Alteplase Urokinase Tenecteplase WX-UK1 Lanoteplase
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Basophil count ( 32888494) Blood protein levels ( 29875488) Eosinophil percentage of white cells ( 32888494) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 32203549) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Plateletcrit ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	20 interacting genes: EEF1A1 ELAVL1 FAP FYN HCK IGF2R IL6ST ITGAM ITGB1 JAK1 KNG1 LRP1 LRP1B MMP12 PFN2 PLAU SRPX2 SURF2 TYK2 VTN
Entrez ID		5217	5329
HPRD ID		01451	01421
Ensembl ID		ENSG00000070087	ENSG00000011422
Uniprot IDs		P35080	M0R1I2 Q03405
PDB IDs		1D1J	1YWH 2FD6 2I9B 3BT1 3BT2 3U73 3U74 4K24 4QTI
Enriched GO Terms of Interacting Partners?
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