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PFN2 and ACTG1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
PFN2
ACTG1
Description
profilin 2
actin gamma 1
Image
GO Annotations
Cellular Component
Cytoplasm
Cytoskeleton
Extracellular Exosome
Extracellular Space
Nucleus
Cytosol
Cytoskeleton
Actin Filament
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Membrane
Apical Junction Complex
Extracellular Exosome
Blood Microparticle
Dense Body
Molecular Function
Actin Binding
Actin Monomer Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
ATPase Activity
Structural Constituent Of Cytoskeleton
Protein Binding
Profilin Binding
ATP Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Structural Constituent Of Postsynaptic Actin Cytoskeleton
Biological Process
Negative Regulation Of Epithelial Cell Migration
Actin Cytoskeleton Organization
Regulation Of Actin Filament Polymerization
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Actin Filament Polymerization
Positive Regulation Of Actin Filament Bundle Assembly
Positive Regulation Of ATPase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Protein Stabilization
Positive Regulation Of Stress Fiber Assembly
Negative Regulation Of Ruffle Assembly
Angiogenesis
Morphogenesis Of A Polarized Epithelium
Retina Homeostasis
Positive Regulation Of Gene Expression
Positive Regulation Of Cell Migration
Cell Junction Assembly
Maintenance Of Blood-brain Barrier
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Ephrin Receptor Signaling Pathway
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Membrane Organization
Platelet Aggregation
Positive Regulation Of Wound Healing
Postsynaptic Actin Cytoskeleton Organization
Tight Junction Assembly
Regulation Of Transepithelial Transport
Protein Localization To Bicellular Tight Junction
Pathways
Signaling by ROBO receptors
RHO GTPases Activate Formins
RHO GTPases Activate Formins
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Gap junction degradation
Formation of annular gap junctions
Regulation of actin dynamics for phagocytic cup formation
Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
EPH-ephrin mediated repulsion of cells
Adherens junctions interactions
Adherens junctions interactions
Recycling pathway of L1
Recycling pathway of L1
VEGFA-VEGFR2 Pathway
Interaction between L1 and Ankyrins
Interaction between L1 and Ankyrins
Cell-extracellular matrix interactions
RHO GTPases activate IQGAPs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate WASPs and WAVEs
RHO GTPases Activate Formins
RHO GTPases Activate Formins
MAP2K and MAPK activation
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Clathrin-mediated endocytosis
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
FCGR3A-mediated phagocytosis
FCGR3A-mediated phagocytosis
Drugs
Triglyme
Pentaglyme
Copper
Artenimol
Diseases
GWAS
Fish- and plant-related diet (
32066663
)
Hand grip strength (
29313844
)
Refractive error (
32231278
)
Interacting Genes
34 interacting genes:
ACTB
ACTG1
ANTKMT
BIRC2
CCDC113
DDX11
DLST
DNM1
EEF1A1
ERCC6
EVL
FHOD1
FLT3LG
FMNL1
GOLGB1
HTT
IK
IVNS1ABP
MSANTD3
MYPOP
NDUFB8
PLAUR
PTPRS
RAP1GAP
RNF146
ROCK1
RPS10
SEPTIN5
SGTA
SNTA1
SYN1
TERF1
VASP
WDR33
68 interacting genes:
ABLIM1
ACTB
ANXA5
ATF7IP
BCAP31
BIN1
BRCA1
CAP1
CAP2
CAPZA3
CCDC22
CDC37
CDKN2A
CFL1
CFL2
COTL1
CTBP2
CTTN
CYBB
DISC1
DNASE1
DSTN
DUX4
DYNLL1
EHHADH
EIF6
FHOD1
FPR1
GIT2
GSN
GZMA
GZMK
HRAS
HSPB2
LGALS13
LIG4
LINC01554
LSP1
MAP1A
MAPK6
MAPT
MCPH1
MYO1A
MYOC
NDRG1
NR3C2
NTAQ1
PFN2
PLD1
PLEC
PPP1R9A
PRSS23
PSEN2
PTPRO
RPS6KA5
SCIN
SH3GL2
SRPK2
ST3GAL3
SUMO4
TMSB4X
TMSB4Y
TNIK
VASP
VIL1
WASF1
WASL
WIPF1
Entrez ID
5217
71
HPRD ID
01451
00017
Ensembl ID
ENSG00000070087
ENSG00000184009
Uniprot IDs
P35080
P63261
PDB IDs
1D1J
5JLH
6CXI
6CXJ
6G2T
6V62
6V63
6WK1
6WK2
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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