PFN2 and RNF146

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PFN2	RNF146
Description		profilin 2	ring finger protein 146
Image
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding ATPase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity Poly-ADP-D-ribose Binding
	Biological Process	Negative Regulation Of Epithelial Cell Migration Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Negative Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of ATPase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Protein Stabilization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly	Ubiquitin-dependent Protein Catabolic Process Wnt Signaling Pathway Protein Autoubiquitination Protein K48-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Signaling by ROBO receptors RHO GTPases Activate Formins RHO GTPases Activate Formins	TCF dependent signaling in response to WNT Degradation of AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
Drugs		Triglyme Pentaglyme
Diseases
GWAS		Fish- and plant-related diet ( 32066663)	Breast cancer ( 18326623) Diverticular disease ( 30177863) Food addiction ( 27106561) Intracranial volume ( 22504418) Subcortical brain region volumes ( 25607358) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		34 interacting genes: ACTB ACTG1 ANTKMT BIRC2 CCDC113 DDX11 DLST DNM1 EEF1A1 ERCC6 EVL FHOD1 FLT3LG FMNL1 GOLGB1 HTT IK IVNS1ABP MSANTD3 MYPOP NDUFB8 PLAUR PTPRS RAP1GAP RNF146 ROCK1 RPS10 SEPTIN5 SGTA SNTA1 SYN1 TERF1 VASP WDR33	11 interacting genes: KASH5 NDUFAF3 PFN2 TGFBR1 TRAF2 TUBGCP4 UBE2D2 UBE2G2 UBE2H XRCC1 XRCC6
Entrez ID		5217	81847
HPRD ID		01451	11511
Ensembl ID		ENSG00000070087	ENSG00000118518
Uniprot IDs		P35080	Q9NTX7
PDB IDs		1D1J	2D8T 3V3L 6CF6
Enriched GO Terms of Interacting Partners?
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