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XIAP and MCRS1
Data Source:
BioGRID
(two hybrid)
XIAP
MCRS1
Description
X-linked inhibitor of apoptosis
microspherule protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Polysome
Dendrite
Ino80 Complex
Perikaryon
NSL Complex
MLL1 Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
G-quadruplex RNA Binding
Protein Binding
Poly(U) RNA Binding
Poly(G) Binding
Biological Process
Cellular Response To DNA Damage Stimulus
Wnt Signaling Pathway
Protein Ubiquitination
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Linear Polyubiquitination
DNA Repair
DNA Recombination
Cellular Protein Modification Process
Viral Process
Protein Deubiquitination
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleolus
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
HATs acetylate histones
UCH proteinases
DNA Damage Recognition in GG-NER
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes
92 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
ELAVL1
ERCC3
FAF1
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSPA1A
HTRA1
HTRA2
IKBKE
INPP5D
KCNJ6
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK2
RIPK3
RIPK4
RUNX1T1
SEPTIN4
SERTAD1
SQSTM1
SSX2IP
STRADB
STUB1
TAB1
TAB2
TBK1
TGFBR1
TLE3
TRAF6
TRIM32
TRIM8
TTC23
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
126 interacting genes:
AGGF1
AXIN2
BACH2
BEND3
BHLHA9
BHLHE40
BLM
BRD8
BRMS1
BRMS1L
C18orf25
C2CD6
C7orf57
C8orf34
CARD9
CAVIN2
CBY2
CCDC13
CCDC136
CCDC85B
CCHCR1
CCNH
CDCA7L
CEP44
CEP70
CNTROB
COIL
CREB3L3
CSRNP1
CYSRT1
CYTIP
DAXX
DRAP1
DVL2
EGR2
ERF
EVI5
FAM9A
FNDC8
FSD2
FXR1
FXR2
GAS7
GCC1
GEM
GIGYF1
GOLGA2
GPBP1
HMBOX1
HOOK2
IKZF1
IKZF3
IKZF4
INO80E
INSYN1
JAKMIP1
KANK2
KAT7
KDM1A
KIAA1958
KRT35
KRTAP10-7
KRTAP2-3
KRTAP2-4
KXD1
LIG4
LSM6
LZTS1
MAGEA11
MAGEA6
MAPK9
MED4
MEOX1
MFAP1
MIER2
MIER3
NAA10
NAB2
NKAPD1
NOP2
OSBPL3
PBK
PBX2
PCM1
PHC2
PIBF1
PINX1
PKNOX2
PPP1R13B
PRMT5
PSTPIP1
PTEN
RABEP1
RALYL
RARA
RETREG3
RIPPLY3
SH2B2
SNAPC5
SP4
SRRM4
SSMEM1
SUV39H1
TADA2B
TBC1D1
TERT
TFAP4
TLE5
TNIP1
TNNI1
TP63
TRIM37
TRIM41
TSPYL2
UPF3B
USHBP1
WASHC3
WBP11
XIAP
ZBTB22
ZCCHC10
ZCCHC12
ZNF23
ZNF639
ZNF8
ZRANB1
Entrez ID
331
10445
HPRD ID
02094
11298
Ensembl ID
ENSG00000101966
ENSG00000187778
Uniprot IDs
B2R9R2
P98170
A0A024R134
Q96EZ8
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
Enriched GO Terms of Interacting Partners
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