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MCRS1 and BLM
Data Source:
BioGRID
(two hybrid)
MCRS1
BLM
Description
microspherule protein 1
BLM RecQ like helicase
Image
No pdb structure
GO Annotations
Cellular Component
Histone Acetyltransferase Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endoplasmic Reticulum
Polysome
Dendrite
Ino80 Complex
Perikaryon
NSL Complex
MLL1 Complex
Nuclear Chromosome
Chromosome, Telomeric Region
Lateral Element
Nucleus
Nucleoplasm
Replication Fork
Chromosome
Nucleolus
Cytoplasm
Cytosol
Nuclear Matrix
PML Body
Protein-containing Complex
Molecular Function
G-quadruplex RNA Binding
Protein Binding
Poly(U) RNA Binding
Poly(G) Binding
Four-way Junction DNA Binding
Y-form DNA Binding
Bubble DNA Binding
P53 Binding
DNA Binding
DNA Helicase Activity
Single-stranded DNA Binding
Helicase Activity
Protein Binding
ATP Binding
DNA-dependent ATPase Activity
Zinc Ion Binding
Four-way Junction Helicase Activity
ATPase Activity
Annealing Helicase Activity
Identical Protein Binding
Protein Homodimerization Activity
3'-5' DNA Helicase Activity
G-quadruplex DNA Binding
Forked DNA-dependent Helicase Activity
Telomeric D-loop Binding
Telomeric G-quadruplex DNA Binding
8-hydroxy-2'-deoxyguanosine DNA Binding
Biological Process
DNA Repair
DNA Recombination
Cellular Protein Modification Process
Viral Process
Protein Deubiquitination
Histone H4-K5 Acetylation
Histone H4-K8 Acetylation
Histone H4-K16 Acetylation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Protein Localization To Nucleolus
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
DNA Strand Renaturation
DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Mitotic G2 DNA Damage Checkpoint
Response To X-ray
Replication Fork Processing
DNA Duplex Unwinding
G-quadruplex DNA Unwinding
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of DNA Recombination
Replication Fork Protection
Protein Complex Oligomerization
Protein Homooligomerization
Negative Regulation Of Cell Division
Telomeric D-loop Disassembly
Cellular Response To Ionizing Radiation
Cellular Response To Hydroxyurea
Cellular Response To Camptothecin
Regulation Of DNA-dependent DNA Replication
T-circle Formation
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
HATs acetylate histones
UCH proteinases
DNA Damage Recognition in GG-NER
Processive synthesis on the C-strand of the telomere
SUMOylation of DNA damage response and repair proteins
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
Resolution of D-loop Structures through Holliday Junction Intermediates
Homologous DNA Pairing and Strand Exchange
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
Defects in RecQ helicases, including: Bloom's syndrome; Werner's syndrome; Rothmund-Thomson syndrome
GWAS
Coronary artery disease (
32469254
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
126 interacting genes:
AGGF1
AXIN2
BACH2
BEND3
BHLHA9
BHLHE40
BLM
BRD8
BRMS1
BRMS1L
C18orf25
C2CD6
C7orf57
C8orf34
CARD9
CAVIN2
CBY2
CCDC13
CCDC136
CCDC85B
CCHCR1
CCNH
CDCA7L
CEP44
CEP70
CNTROB
COIL
CREB3L3
CSRNP1
CYSRT1
CYTIP
DAXX
DRAP1
DVL2
EGR2
ERF
EVI5
FAM9A
FNDC8
FSD2
FXR1
FXR2
GAS7
GCC1
GEM
GIGYF1
GOLGA2
GPBP1
HMBOX1
HOOK2
IKZF1
IKZF3
IKZF4
INO80E
INSYN1
JAKMIP1
KANK2
KAT7
KDM1A
KIAA1958
KRT35
KRTAP10-7
KRTAP2-3
KRTAP2-4
KXD1
LIG4
LSM6
LZTS1
MAGEA11
MAGEA6
MAPK9
MED4
MEOX1
MFAP1
MIER2
MIER3
NAA10
NAB2
NKAPD1
NOP2
OSBPL3
PBK
PBX2
PCM1
PHC2
PIBF1
PINX1
PKNOX2
PPP1R13B
PRMT5
PSTPIP1
PTEN
RABEP1
RALYL
RARA
RETREG3
RIPPLY3
SH2B2
SNAPC5
SP4
SRRM4
SSMEM1
SUV39H1
TADA2B
TBC1D1
TERT
TFAP4
TLE5
TNIP1
TNNI1
TP63
TRIM37
TRIM41
TSPYL2
UPF3B
USHBP1
WASHC3
WBP11
XIAP
ZBTB22
ZCCHC10
ZCCHC12
ZNF23
ZNF639
ZNF8
ZRANB1
38 interacting genes:
ATR
ATRX
BRIP1
CASP3
CHAF1A
CHEK1
DNA2
EXO1
FANCD2
FBXW7
FEN1
JUN
MCRS1
MIB1
MLH1
MX1
NEK11
PSMD3
RAD51
RAD51D
RNF8
RPA1
SMC1A
SPIDR
SUMO1
SUMO2
SUMO3
SYN1
TERF1
TERF2
TOP3A
TOPBP1
TP53
TP53BP1
TRIM49
UBE2I
UPF2
WRN
Entrez ID
10445
641
HPRD ID
11298
05211
Ensembl ID
ENSG00000187778
ENSG00000197299
Uniprot IDs
A0A024R134
Q96EZ8
B7ZKN7
H0YNU5
P54132
PDB IDs
2KV2
2MH9
2RRD
3WE2
3WE3
4CDG
4CGZ
4O3M
5LUP
5MK5
5U6K
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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