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XIAP and CCNB1
Data Source:
BioGRID
(pull down)
XIAP
CCNB1
Description
X-linked inhibitor of apoptosis
cyclin B1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Cyclin-dependent Protein Kinase Holoenzyme Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Matrix
Centrosome
Cytosol
Membrane
Cyclin B1-CDK1 Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Patched Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin-like Protein Ligase Binding
Cyclin-dependent Protein Serine/threonine Kinase Activator Activity
Biological Process
Cellular Response To DNA Damage Stimulus
Wnt Signaling Pathway
Protein Ubiquitination
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Linear Polyubiquitination
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Oocyte Maturation
In Utero Embryonic Development
Negative Regulation Of Protein Phosphorylation
Transcription Initiation From RNA Polymerase II Promoter
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Mitotic Spindle Organization
Mitotic Nuclear Envelope Disassembly
Mitotic Metaphase Plate Congression
Spermatogenesis
Response To Mechanical Stimulus
Negative Regulation Of Gene Expression
Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Catabolic Process
Positive Regulation Of MRNA 3'-end Processing
Positive Regulation Of Histone Phosphorylation
Tissue Regeneration
Response To Drug
Mitotic Cell Cycle Phase Transition
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Mitotic Cell Cycle
Response To DDT
Positive Regulation Of Fibroblast Proliferation
Digestive Tract Development
Cell Division
Regulation Of Cell Cycle
Positive Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Ventricular Cardiac Muscle Cell Development
Positive Regulation Of Cardiac Muscle Cell Proliferation
Regulation Of Chromosome Condensation
Protein-containing Complex Assembly
Cellular Response To Iron(III) Ion
Cellular Response To Fatty Acid
Cellular Response To Organic Cyclic Compound
Cellular Response To Hypoxia
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Mitochondrial ATP Synthesis Coupled Electron Transport
Histone H3-S10 Phosphorylation Involved In Chromosome Condensation
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
E2F-enabled inhibition of pre-replication complex formation
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdc20 mediated degradation of Cyclin B
Regulation of APC/C activators between G1/S and early anaphase
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
MASTL Facilitates Mitotic Progression
Resolution of Sister Chromatid Cohesion
Condensation of Prometaphase Chromosomes
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Initiation of Nuclear Envelope (NE) Reformation
Nuclear Pore Complex (NPC) Disassembly
Depolymerisation of the Nuclear Lamina
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
Mitotic Prophase
Cyclin A/B1/B2 associated events during G2/M transition
G2/M DNA replication checkpoint
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
The role of GTSE1 in G2/M progression after G2 checkpoint
Transcriptional regulation by RUNX2
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes
92 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
ELAVL1
ERCC3
FAF1
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSPA1A
HTRA1
HTRA2
IKBKE
INPP5D
KCNJ6
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK2
RIPK3
RIPK4
RUNX1T1
SEPTIN4
SERTAD1
SQSTM1
SSX2IP
STRADB
STUB1
TAB1
TAB2
TBK1
TGFBR1
TLE3
TRAF6
TRIM32
TRIM8
TTC23
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
59 interacting genes:
ANAPC11
ARID4A
BRCA1
CCNB1IP1
CCNF
CDC20
CDC25A
CDC25C
CDC27
CDC34
CDC6
CDK1
CDKN1A
CDKN1B
CDT1
EP300
FLNA
FZR1
GADD45A
GADD45B
GADD45G
H1-1
H1-5
HERC5
ITPR1
KAT5
MAP4
MEF2C
MOK
OTUD7B
PBK
PCNA
PIN1
PKMYT1
PLK1
POLA1
PRC1
PRKDC
PRKN
PTCH1
PTMA
RALBP1
RB1
RPA1
RUNX2
SQSTM1
TGFBR2
TP53BP1
TP73
TSC1
TSPYL2
TULP3
UBE2C
UBE2D2
UBE2N
UBE2S
UBE3C
UBE3D
XIAP
Entrez ID
331
891
HPRD ID
02094
00454
Ensembl ID
ENSG00000101966
ENSG00000134057
Uniprot IDs
B2R9R2
P98170
P14635
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
2B9R
2JGZ
4Y72
4YC3
5HQ0
5LQF
6GU2
6GU3
6GU4
Enriched GO Terms of Interacting Partners
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