XIAP and UBE2V1

Data Source:
BioGRID (two hybrid)

		XIAP	UBE2V1
Description		X-linked inhibitor of apoptosis	ubiquitin conjugating enzyme E2 V1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Spindle Microtubule	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Ubiquitin Conjugating Enzyme Complex Protein-containing Complex UBC13-UEV1A Complex Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Wnt Signaling Pathway Protein Ubiquitination Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Innate Immune Response Regulation Of Inflammatory Response Neuron Apoptotic Process Regulation Of Cell Cycle Copper Ion Homeostasis Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Linear Polyubiquitination	Activation Of MAPK Activity Protein Polyubiquitination Regulation Of DNA Repair Postreplication Repair Regulation Of Transcription, DNA-templated JNK Cascade Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE AEG35156
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		92 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BOLA1 BOLA2 BOLA2B BRCA1 CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 ELAVL1 ERCC3 FAF1 GCC1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSPA1A HTRA1 HTRA2 IKBKE INPP5D KCNJ6 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MCRS1 MDM2 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 PIBF1 PPIH PPM1K QARS1 RAF1 RFC5 RIPK2 RIPK3 RIPK4 RUNX1T1 SEPTIN4 SERTAD1 SQSTM1 SSX2IP STRADB STUB1 TAB1 TAB2 TBK1 TGFBR1 TLE3 TRAF6 TRIM32 TRIM8 TTC23 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1	47 interacting genes: ARIH2 BIRC2 BIRC3 BIRC8 CTAG1A CTAG1B DAZAP2 DTX3 DZIP3 FAM168A KITLG MAP3K1 MID1 MKRN3 PELI1 PELI3 PRKN PSMD14 RC3H1 RC3H2 RNF10 RNF111 RNF14 RNF144A RNF185 RNF2 RNF5 SHISA4 SMURF1 STUB1 SUMO4 TRAF2 TRAF3IP2 TRAF6 TRIM25 TRIM32 TRIM39 TRIM5 TRIM8 UBC UBE2N UBOX5 UBQLN1 UBQLN2 XBP1 XIAP ZNRF1
Entrez ID		331	7335
HPRD ID		02094	04294
Ensembl ID		ENSG00000101966	ENSG00000244687
Uniprot IDs		B2R9R2 P98170	G3V2F7 Q13404
PDB IDs		1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI	2A4D 2C2V 2HLW 6D6I
Enriched GO Terms of Interacting Partners?
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