Description |
X-linked inhibitor of apoptosis |
checkpoint kinase 1 |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- XL844
- Enzastaurin
- CHIR-124
- N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
- 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
- (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
- 2-(cyclohexylamino)benzoic acid
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
- (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
- 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
- (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
- 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
- (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
- 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
- 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
- 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
- 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
- (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
- (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
- N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
- (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
- 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
- 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
- 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
- 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
- REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
- 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
- N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
- 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
- [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
- 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
- 6-MORPHOLIN-4-YL-9H-PURINE
- 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
- Fostamatinib
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Diseases |
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GWAS |
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Interacting Genes |
92 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
ELAVL1
ERCC3
FAF1
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSPA1A
HTRA1
HTRA2
IKBKE
INPP5D
KCNJ6
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK2
RIPK3
RIPK4
RUNX1T1
SEPTIN4
SERTAD1
SQSTM1
SSX2IP
STRADB
STUB1
TAB1
TAB2
TBK1
TGFBR1
TLE3
TRAF6
TRIM32
TRIM8
TTC23
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
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51 interacting genes:
AATF
AKT1
APP
ATM
ATR
ATXN3
BCL2L1
BLM
BRCA1
BRCA2
CDC25A
CDC25B
CDC25C
CHUK
CLSPN
CNTN2
CSNK2B
CUL1
CUL4A
DTL
FANCE
HSP90AA1
ILKAP
LATS2
MAPT
MCM6
MCM7
MCPH1
MDM4
PIGM
PRKAA1
PRKDC
RAD23A
RAD51
RB1
RELA
SMAD4
TIMELESS
TLK1
TOPBP1
TP53
TP53BP1
UBA1
UBA2
UBB
UBE2T
USP3
XIAP
XPO1
XRCC6
YWHAG
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Entrez ID |
331 |
1111 |
HPRD ID |
02094 |
04356 |
Ensembl ID |
ENSG00000101966
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ENSG00000149554
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Uniprot IDs |
B2R9R2
P98170
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B4DT73
E7EPP6
O14757
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PDB IDs |
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
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1IA8
1NVQ
1NVR
1NVS
1ZLT
1ZYS
2AYP
2BR1
2BRB
2BRG
2BRH
2BRM
2BRN
2BRO
2C3J
2C3K
2C3L
2CGU
2CGV
2CGW
2CGX
2E9N
2E9O
2E9P
2E9U
2E9V
2GDO
2GHG
2HOG
2HXL
2HXQ
2HY0
2QHM
2QHN
2R0U
2WMQ
2WMR
2WMS
2WMT
2WMU
2WMV
2WMW
2WMX
2X8D
2X8E
2X8I
2XEY
2XEZ
2XF0
2YDI
2YDJ
2YDK
2YER
2YEX
2YM3
2YM4
2YM5
2YM6
2YM7
2YM8
2YWP
3F9N
3JVR
3JVS
3NLB
3OT3
3OT8
3PA3
3PA4
3PA5
3TKH
3TKI
3U9N
4FSM
4FSN
4FSQ
4FSR
4FST
4FSU
4FSW
4FSY
4FSZ
4FT0
4FT3
4FT5
4FT7
4FT9
4FTA
4FTC
4FTI
4FTJ
4FTK
4FTL
4FTM
4FTN
4FTO
4FTQ
4FTR
4FTT
4FTU
4GH2
4HYH
4HYI
4JIK
4QYE
4QYF
4QYG
4QYH
4RVK
4RVL
4RVM
5DLS
5F4N
5OOP
5OOR
5OOT
5OP2
5OP4
5OP5
5OP7
5OPB
5OPR
5OPS
5OPU
5OPV
5OQ5
5OQ6
5OQ7
5OQ8
5WI2
6FC8
6FCF
6FCK
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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