Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
XIAP and ACVRL1
Data Source:
HPRD
(in vitro)
XIAP
ACVRL1
Description
X-linked inhibitor of apoptosis
activin A receptor like type 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
Receptor Complex
BMP Receptor Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Serine/threonine Kinase Activity
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Transforming Growth Factor Beta-activated Receptor Activity
Transforming Growth Factor Beta Receptor Activity, Type I
Protein Binding
ATP Binding
Activin Receptor Activity, Type I
Protein Kinase Binding
SMAD Binding
Metal Ion Binding
Activin Binding
Transforming Growth Factor Beta Binding
BMP Receptor Activity
Biological Process
Cellular Response To DNA Damage Stimulus
Wnt Signaling Pathway
Protein Ubiquitination
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Linear Polyubiquitination
Angiogenesis
Regulation Of Endothelial Cell Proliferation
Lymphangiogenesis
Blood Vessel Maturation
Blood Vessel Remodeling
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Endocardial Cushion Morphogenesis
Regulation Of DNA Replication
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Negative Regulation Of Cell Adhesion
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Heart Development
Blood Circulation
Regulation Of Blood Pressure
Negative Regulation Of Cell Population Proliferation
Dorsal/ventral Pattern Formation
Negative Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Negative Regulation Of Cell Growth
Negative Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of BMP Signaling Pathway
Positive Regulation Of Chondrocyte Differentiation
Activin Receptor Signaling Pathway
Wound Healing, Spreading Of Epidermal Cells
Dorsal Aorta Morphogenesis
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Negative Regulation Of Focal Adhesion Assembly
Lymphatic Endothelial Cell Differentiation
Artery Development
Venous Blood Vessel Development
Endothelial Tube Morphogenesis
Retina Vasculature Development In Camera-type Eye
Cellular Response To Growth Factor Stimulus
Cellular Response To Transforming Growth Factor Beta Stimulus
Cellular Response To BMP Stimulus
Endocardial Cushion To Mesenchymal Transition
Negative Regulation Of DNA Biosynthetic Process
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
Signaling by BMP
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
ATP
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Hereditary hemorrhagic telangiectasia (HHT)
GWAS
Hematocrit (
29403010
)
Hemoglobin (
29403010
32888494
)
Hemoglobin levels (
32327693
)
Lymphocyte counts (
32888494
)
Medication use (HMG CoA reductase inhibitors) (
31015401
)
Monocyte count (
32888494
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
32888494
)
Platelet count (
32888494
)
Plateletcrit (
32888494
27863252
)
Urate levels (
23263486
)
White blood cell count (
32888494
27863252
)
Interacting Genes
92 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
ELAVL1
ERCC3
FAF1
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSPA1A
HTRA1
HTRA2
IKBKE
INPP5D
KCNJ6
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK2
RIPK3
RIPK4
RUNX1T1
SEPTIN4
SERTAD1
SQSTM1
SSX2IP
STRADB
STUB1
TAB1
TAB2
TBK1
TGFBR1
TLE3
TRAF6
TRIM32
TRIM8
TTC23
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
13 interacting genes:
ACVR2A
BAMBI
CSNK2B
FKBP1A
GDF2
SMAD1
SNX6
TGFB1
TGFB3
TGFBR1
TGFBR2
TGFBRAP1
XIAP
Entrez ID
331
94
HPRD ID
02094
03181
Ensembl ID
ENSG00000101966
ENSG00000139567
Uniprot IDs
B2R9R2
P98170
A0A0S2Z310
P37023
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
2LCR
3MY0
4FAO
6SF1
6SF2
6SF3
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?