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XIAP and BIRC5
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
HPRD
(in vitro)
XIAP
BIRC5
Description
X-linked inhibitor of apoptosis
baculoviral IAP repeat containing 5
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Nuclear Chromosome
Chromosome, Centromeric Region
Condensed Chromosome Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Midbody
Chromosome Passenger Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Microtubule Binding
Enzyme Binding
Small GTPase Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Chaperone Binding
Biological Process
Cellular Response To DNA Damage Stimulus
Wnt Signaling Pathway
Protein Ubiquitination
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Linear Polyubiquitination
Protein Phosphorylation
Apoptotic Process
Chromosome Segregation
Sensory Perception Of Sound
Positive Regulation Of Cell Population Proliferation
Cytokine-mediated Signaling Pathway
Protein-containing Complex Localization
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
Cell Division
Regulation Of Cell Cycle
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA replication proteins
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
Mitotic Prometaphase
Neddylation
EML4 and NUDC in mitotic spindle formation
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
Reserpine
Berberine
LY2181308
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Blood trace element (Se levels) (
23720494
)
Periodontitis (Mean PAL) (
24024966
)
Interacting Genes
92 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
ELAVL1
ERCC3
FAF1
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSPA1A
HTRA1
HTRA2
IKBKE
INPP5D
KCNJ6
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK2
RIPK3
RIPK4
RUNX1T1
SEPTIN4
SERTAD1
SQSTM1
SSX2IP
STRADB
STUB1
TAB1
TAB2
TBK1
TGFBR1
TLE3
TRAF6
TRIM32
TRIM8
TTC23
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
25 interacting genes:
AURKA
AURKB
AURKC
BIRC2
BIRC3
BIRC6
CASP3
CASP7
CASP9
CCDC85B
CDCA8
CDK1
CDK4
DIABLO
EVI5
FBXL7
H3-4
H3C14
HSP90AA1
INCENP
KCNJ6
RAN
RASA1
XIAP
XPO1
Entrez ID
331
332
HPRD ID
02094
04520
Ensembl ID
ENSG00000101966
ENSG00000089685
Uniprot IDs
B2R9R2
P98170
A0A0B4J1S3
H3BLT4
O15392
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
1E31
1F3H
1XOX
2QFA
2RAW
2RAX
3UEC
3UED
3UEE
3UEF
3UEG
3UEH
3UEI
3UIG
3UIH
3UII
3UIJ
3UIK
4A0I
4A0J
4A0N
6SHO
6YIE
6YIF
6YIH
Enriched GO Terms of Interacting Partners
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