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XIAP and TTC23
Data Source:
BioGRID
(two hybrid)
XIAP
TTC23
Description
X-linked inhibitor of apoptosis
tetratricopeptide repeat domain 23
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Spindle Microtubule
Cilium
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Identical Protein Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Biological Process
Cellular Response To DNA Damage Stimulus
Wnt Signaling Pathway
Protein Ubiquitination
Regulation Of BMP Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Neuron Apoptotic Process
Regulation Of Cell Cycle
Copper Ion Homeostasis
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Protein Linear Polyubiquitination
Positive Regulation Of Smoothened Signaling Pathway
Pathways
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
SMAC, XIAP-regulated apoptotic response
Deactivation of the beta-catenin transactivating complex
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Regulation of PTEN localization
Regulation of PTEN stability and activity
Regulation of the apoptosome activity
Drugs
1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide
Dequalinium
N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
AEG35156
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes
92 interacting genes:
ACVRL1
AFP
AIFM1
AKT1
AKT2
BCL2
BIRC5
BOLA1
BOLA2
BOLA2B
BRCA1
CASP10
CASP3
CASP7
CASP9
CCNB1
CDC42
CDK1
CHEK1
CKS1B
COMMD1
DIABLO
DNM2
DTX3
DYNLL2
ELAVL1
ERCC3
FAF1
GCC1
GOLGA2
GSK3B
GSPT1
HNRNPA1
HSPA1A
HTRA1
HTRA2
IKBKE
INPP5D
KCNJ6
LONRF1
MAGED1
MAP3K2
MAP3K3
MAP3K7
MCRS1
MDM2
NEK6
NOD1
NOD2
NOTCH1
NTAQ1
PIBF1
PPIH
PPM1K
QARS1
RAF1
RFC5
RIPK2
RIPK3
RIPK4
RUNX1T1
SEPTIN4
SERTAD1
SQSTM1
SSX2IP
STRADB
STUB1
TAB1
TAB2
TBK1
TGFBR1
TLE3
TRAF6
TRIM32
TRIM8
TTC23
UBB
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2I
UBE2J2
UBE2N
UBE2V1
UBE2V2
UBE2W
VPS37C
XAF1
99 interacting genes:
ABI1
ADCY4
ALAS1
APP
BANP
BHLHE40
BLZF1
C1orf109
CBX8
CCDC102B
CCDC24
CCNDBP1
CDK18
CDR2
CNTROB
CREBZF
CYSRT1
DISC1
EFCAB3
FAM161B
FSD2
GOLGA2
GOLGA6L9
GPANK1
GPRASP2
GRIPAP1
HOOK2
HSF2BP
HTT
INSC
IQCE
KASH5
KDM1A
KIAA1328
KLHL42
KRT15
KRT16
KRT27
KRT31
KRT34
KRT36
KRT40
KRTAP10-3
KRTAP10-8
LCN2
LDOC1
LZTS2
MAGED1
MBD3
MDFI
MED12L
MESD
MID2
MKRN3
MTUS2
NOTO
NUTM1
PICK1
PIH1D2
PLEKHG4
PNMA1
PNMA5
POLR2J3
POU6F2
PPP1R16A
PRDM6
PRKAB2
PRPH
PSORS1C2
RAD51D
RBCK1
SPAG11B
SPAG5
SPAG8
SPDEF
SSX2IP
TADA2A
TEX13A
TLE5
TRAF2
TRAPPC6A
TRIB3
TRIM10
TRIM32
TRIM54
TRIM73
TRIP6
TSGA10IP
UBXN11
USHBP1
XIAP
XRN2
ZBED1
ZBTB16
ZBTB42
ZDHHC17
ZFHX3
ZFYVE26
ZIM2
Entrez ID
331
64927
HPRD ID
02094
07777
Ensembl ID
ENSG00000101966
ENSG00000103852
Uniprot IDs
B2R9R2
P98170
Q5W5X9
PDB IDs
1C9Q
1F9X
1G3F
1G73
1I3O
1I4O
1I51
1KMC
1NW9
1TFQ
1TFT
2ECG
2JK7
2KNA
2OPY
2OPZ
2POI
2POP
2QRA
2VSL
3CLX
3CM2
3CM7
3EYL
3G76
3HL5
3UW4
3UW5
4EC4
4HY0
4IC2
4IC3
4J3Y
4J44
4J45
4J46
4J47
4J48
4KJU
4KJV
4KMP
4MTZ
4OXC
4WVS
4WVT
4WVU
5C0K
5C0L
5C3H
5C3K
5C7A
5C7B
5C7C
5C7D
5C83
5C84
5M6E
5M6F
5M6H
5M6L
5M6M
5O6T
5OQW
6EY2
6GJW
6QCI
Enriched GO Terms of Interacting Partners
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